Fatty acid synthase 3D structures

3D structures of fatty acid synthase

Updated on 09-June-2025

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• Fatty acid synthase; Domains – KS-MAT 2-963; MAT 422-823; dehydratase 858-1102; core modifying 855-2511;enoyl-ACP-reductase 1529-1867; ACP 2114-2202; thioesterase 2221-2502
  • 9b7z, 9b80 – hFAS 1-854 – human – Cryo EM
    
  • 8eyi, 8eyk – hFAS 854-2511 – Cryo EM
    
  • 1xkt, 4z49 – hFAS thioesterase domain
    
  • 8g7x, 8zev – hFAS dehydratase domain
  • 2jfd – hFAS MAT domain
    
  • 3hhd - hFAS KS-MAT domain
    
  • 4w82 – hFAS enoyl- ACP-reductase domain
    
  • 2cf2, 2vz8 – pFAS – pig
    
  • 2png – FAS ACP domain – rat
    
  • 5my2 – FAS KS-MAT DI domain – mouse
    
  • 6fn6 – FAS – Drosophila melanogaster
    
  • 2uv8, 3hmj, 6ql9 – yFAS α+β subunits + FMN - yeast
    
  • 6jsh, 6jsi, 6ql5, 6ql6, 6ta1, 6u5t, 6u5u, 6wc7, 8prw, 8psm - yFAS α+β subunits + FMN – Cryo EM
    
  • 2pff, 2was, 2ml8 – yFAS α subunit
    
  • 1kp9 – MtFAS CmaA1 – Mycobacterium tuberculosis
    
  • 4v8w, 6gjc – MtFAS I – Cryo-EM
    
  • 4v8l – FAS – Mycobacterium smegmatis – Cryo-EM
    
  • 4v58 – TlFAS – Thermomyces lanuginosus
    
  • 6u5v, 6u5w, 7tui - CaFAS α+β subunits + FMN – Candida albicans - Cryo EM
    
  • 7bc4 - PpFAS α+β subunits – Pischia pastoris - Cryo EM
    
  • 7bc5 - PpFAS α subunit ACP domain - Cryo EM
    
  • 7q5s - FAS – Chaetonium thermophilum - Cryo EM
    
• FAS complex with fatty acid
  • 9mj9 – hFAS 1-854 + Ser-ACP – Cryo EM
  • 3tjm – hFAS thioesterase domain + fatty acid
    
  • 8pcg, 8prv, 8ps1, 8ps2, 8ps8, 8ps9, 8psa, 8psf, 8psj, 8psk, 8psl, 8psp - yFAS thioesterase domain + ACP – Cryo EM
  • 1kpg – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine
    
  • 1kph – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine
    
  • 1kpi – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine
    
  • 3hem - MtFAS CmaA1 + dioctylamine
    
• FAS complex with reactants
  • 8vle, 8vlp, 8vm0, 8vm5, 8vm6, 8vm7, 8vmc, 8vmd - hFAS + NADP – Cryo EM
  • 8vf7, 8vg4 - hFAS + NADP + Ser-ACP – Cryo EM
  • 2jfk – hFAS MAT domain + malonyl CoA
    
  • 2vz9 – pFAS + NADP
    
  • 5my0 - mFAS KS-MAT domain + malonyl CoA
    
  • 6rop - mFAS KS-MAT domain + octanoyl CoA
    
  • 2wat – yFAS α subunit + CoA
    
  • 4v59 – TlFAS + NADP
    
• FAS complex with protein
  • 2cg5 - hFAS ACP domain + AASD-PPT
    
  • 6ql7 – yFAS α+β subunits + translation machinery-associated protein 17
    
• FAS complex with inhibitor
  • 7mhd, 7mhe – hFAS thioesterase domain + inhibitor
    
  • 2px6 – hFAS thioesterase domain + orlistat
    
  • 4piv, 5c37, 6nna – hFAS (mutant) + NADP + inhibitor
    
  • 2vkz - yFAS α+β subunits + cerulenin
    
  • 8gkc – hFAS core modifying domain + drug – Cryo EM
    

For FAS acyl carrier protein see Acyl carrier protein

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Michal Harel, Openfox