Thioredoxin

spinqualitylabelsall models Human thioredoxin (PDB entry 1ert) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Thioredoxin (Trx) is an enzyme which facilitates, in its reduced form, the reduction of proteins by cysteine thiol-disulfide exchange. They contain a CXXC motif. Trx-1 is a mammalian cellular protein. Trx-2 is mitochondria-specific. Trx C,M,X,Y are found in prokaryotes. Trx F,H,O are found in eukaryotes. There are a range of strategies used by the host organism in an attempt to defend itself against pathogen invasion. Among these is the release of oxidants, such as reactive oxygen species (ROS), which at defined physiological concentrations act as signaling messengers. However, in supraphysiological concentrations, their reactivity has deleterious cellular consequences, causing damage to macromolecules such as proteins, lipids and DNA, thus impairing the system's homeostasis (SIES, 1985). It is therefore an alternative used to inhibit the pathogen and prevent infection of the organism. Relevance Serum Trx level is a predictor of steatohepatitis. Disease Trx is involved in a wide range of human diseases and conditions including cancer, viral diseases, aging, cardiac conditions and more. Structural highlights The active site motif Cys-Gly-Pro-Cys is involved in the reduction of disulfide bonds in proteins 3D Structures of Thioredoxin Thioredoxin 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Laura Maria Batista Leal, Joel L. Sussman, Michal Harel