9fu2 | pdb_00009fu2

Smooth Muscle Myosin II in complex with MT-228

spinqualitylabelsall models 9fu2, resolution 2.58Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9fu2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.581Å Ligands: A1IGE, ADP, CL, DMS, EDO, MG, MLY, VO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease MYH11_HUMAN Familial aortic dissection;Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22);Megacystis-microcolon-intestinal hypoperistalsis syndrome;Familial thoracic aortic aneurysm and aortic dissection. A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Function MYH11_HUMAN Muscle contraction.

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