9nyy | pdb_00009nyy

Nucleic acid bound human SLFN14, State 1

spinqualitylabelsall models 9nyy, resolution 2.73Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9nyy is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.73Å Ligands: MG, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease SLN14_HUMAN Autosomal dominant thrombocytopenia with platelet secretion defect. The disease is caused by variants affecting the gene represented in this entry. Function SLN14_HUMAN Shows no ribosome-associated and endoribonuclease activities. Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.[UniProtKB:G1SRW8]

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