Galectin 3D structures

3D structures of galectin

Updated on 16-July-2025

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• Galectin-1
  • 1hlc – hGAL-1 + lactose – human
    
  • 3w58, 3w59 – hGAL-1 - human
    
  • 2km2 – hGAL-1 - NMR
    
  • 1w6n, 1w6q - hGAL-1 (mutant)
    
  • 1hlc – hGAL-1 + lactose
    
  • 1w6o, 2zkn, 6m5y – hGAL-1 (mutant) + lactose
    
  • 4q26, 4q27, 4xbl - hGAL-1 + acetyl lactosamine
    
  • 6b94 - hGAL-1 + lactulose
    
  • 7lta - hGAL-1 + trehalose
    
  • 1w6p – hGAL-1 (mutant) + acetyl lactosamine
    
  • 4y1u, 4y1v, 4y1x, 4y1y, 4y1z, 4y20, 4y22, 4y24 - hGAL-1 N-terminal + Gal-GlcNac
    
  • 1gzw – hGAL-1 + BGAL
    
  • 1w6m – hGAL(mutant) + BGAL
    
  • 3oy8 – hGAL-1 + lactobionic acid
    
  • 3oyw, 8r74, 8rdc - hGAL-1 + thio-digalactoside
    
  • 3t2t, 4q1p, 4q1r, 4q2f, 6f83, 7nml – hGAL-1 + inhibitor
    
  • 5mwt, 5mwx, 8b0w, 8b0z – hGAL-1 N-terminal CRD + ligand
    
  • 1slt, 1sla, 1slb, 1slc – GAL-1 + BGAL – bovine
    
  • 3m2m, 4ga9 - rGAL-1 + lactose – rat
    
  • 4no4 - rGAL-1 (mutant) + lactose
    
  • 4lbq – mGAL-1 – mouse
    
  • 1gan – tGAL-1 + BGAL – toad
    
  • 1a78 – tGAL-1 + thio-digalactose
    
  • 6e20 – GAL-1 – zebrafish
    
• Galectin-2
  • 5dg1, 5dg2, 5ews - hGAL-2 N-terminal
    
  • 2ymz – GAL-2 – chicken
    
  • 1ul9 – CchGAL-2 – Coprinopsis cinerea
    
  • 1ulc – CcGAL-2 + lactose
    
  • 1ulg - CcGAL-2 + BGAL
    
  • 1uld, 2wkk – CcGAL-2 + BGAL + fucose
    
  • 1ule, 1ulf – CcGAL-2 + polysaccharide
    
• Galectin-3; Domain – CRD 113-250
  • 3zsk, 3zsl, 3zsm, 6exy, 5nfc, 6h64 – hGAL-3 CRD
    
  • 6f2q - hGAL-3 CRD – neutron
    
  • 6fof - hGAL-3 CRD (mutant)
    
  • 1a3k, 1kjl, 2nmn – hGAL-3 CRD + BGAL
    
  • 2nmo - hGAL-3 CRD + glucose + BGAL
    
  • 2nn8, 3aye, 3zsj, 4r9a, 4r9b, 4r9c, 4r9d, 4rl7, 6eym, 6y4c, 6y78 - hGAL-3 CRD + lactose
    
  • 1kjr, 4xbn, 5nf7, 5nf9, 5nla, 5nlb, 5nfb, 5nfa, 8bz3, 7df5, 7rgx, 7rgy, 7rgz, 7rh0, 7rh1, 7rh3, 7rh4, 7xfa - hGAL-3 CRD + lactosamine derivative
    
  • 7be3 - hGAL-3 CRD + lactose derivative
    
  • 2xg3, 3t1l, 3t1m, 5e88, 5e89, 5e8a, 5exo, 5h9p, 5h9r, 5iuq, 6q0q, 6q17, 7df5, 7rgx, 7rgy, 7rgz, 7rh0, 7rh1, 7rh3, 7rh4, 7xfa, 8itx, 8iu1, 8pbf, 8pf9, 8pff, 8rmt, 8rmu, 8rmv, 8rr7, 8rr8, 8rr9, 8rra, 8rrb, 8rrc, 8rre, 8rrf, 8rrg, 8s67, 9fdb, 9fdc - hGAL-3 CRD + inhibitor
    
  • 8itz, 8z25 - hGAL-3 CRD (mutant) + inhibitor
  • 3aya, 6g0v - hGAL-3 CRD + antigen
    
  • 3ayc, 3ayd, 4jc1, 4jck, 6f6y, 6kxa, 6kxb, 7cxa, 7cxb, 7cxc, 7cxd, 8oji, 8ojk, 8ojm, 8ojo, 8ymd - hGAL-3 CRD + polysaccharide
    
  • 4lbj, 4lbk, 4lbl, 4lbm, 4lbn, 4lbo - hGAL-3 CRD (mutant) + glycosphingolipid
    
  • 4bli, 4blj, 4bm8, 5oax, 5ody, 6i74, 6i75, 6i76, 6i77, 6i78, 8ppn - hGAL-3 CRD + thiogalactoside derivative
    
  • 7rdo, 7rdp, 7zqx - hGAL-3 CRD + galactoside derivative
    
  • 6eol, 6eog, 6tf6, 6tf7 - hGAL-3 CRD + galactose derivative
    
  • 6qge, 6qgf - hGAL-3 CRD + ligand
    
  • 6fk2 - hGAL-3 CRD + lactitol
    
  • 6b8k - hGAL-3 CRD + lactulose
    
  • 6qln, 6qlo, 6qlp, 6qlq, 6qlr, 6qls, 6qlt, 6qlu, 6rhl, 6rhm, 6rzf, 6rzg, 6rzh, 6rzi, 6rzj, 6rzk, 6rzl, 6rzm - hGAL-3 CRD + fluoroaryl monogalactoside derivative
    
  • 7df6, 8ilu, 8z1s, 8z1t, 8zuv - mGAL-3 CRD + inhibitor
    
• Galectin-4; Domains – N-terminal CRD 1-155; C-terminal CRD 173-323
  • 1x50 – hGAL-4 C-terminal CRD – NMR
    
  • 4xzp, 5duu - hGAL-4 N terminal CRD
    
  • 5duv, 5duw, 5dux - hGAL-4 N terminal CRD+ lactose derivative
    
  • 4ylz, 4ym0 - hGAL-4 C-terminal CRD + lacto-neotetraose
    
  • 4ym1, 4ym2, 4ym3, 5cbl - hGAL-4 C-terminal CRD + lactose derivative
    
  • 6wab - hGAL-4 C-terminal CRD + galactose derivative
    
  • 2dyc – mGAL-4 N-terminal CRD
    
  • 3i8t – mGAL-4 N-terminal CRD + lactose
    
• Galectin-5; Residues 1-136
  • 5jp5 – rGAL-5
    
  • 5jpg – rGAL-5 + lactose
    
• Galectin-7
  • 1bkz, 3zxf, 7xac, 7xbl – hGAL-7
    
  • 6vtp, 6vtr, 7n4o, 7n8g, 7n96, 7tkw, 7tky, 7trn - hGAL-7 (mutant)
    
  • 4gal – hGAL-7 + lactose
    
  • 6vtq, 6vts, 7n57, 7n8d, 7n6c, 7rdg, 7tkz, 7tro – hGAL-7 (mutant) + lactose
    
  • 2gal - hGAL-7 + BGAL
    
  • 3gal – hGAL-7 + galactosamine
    
  • 5gal, 4xbq – hGAL-7 + acetyllactosamine
    
  • 6vto, 7tkx – hGAL-7 + pyranosyl-glucose derivative
    
  • 3zxe, 5h9q, 5h9s - hGAL-7 N-terminal + inhibitor
    
  • 4uw3, 4uw4, 4uw5, 4uw6 – hGAL-7 + galactose-based dendron
    
  • 4y26 - hGAL-7 N-terminal + Gal-GlcNac
    
• Galectin-8; Domains – N-terminal CRD 1-154; C-terminal CRD 175-315
  • 2yro – hGAL-8 C-terminal CRD – NMR
    
  • 3ap5, 3apb, 3ap9, 3vkn - hGAL-8 N-terminal CRD
    
  • 3ap4, 3ap6, 3vkl - hGAL-8 N-terminal CRD + lactose
    
  • 3ap7, 3vkm - hGAL-8 N-terminal CRD + sialyllactose
    
  • 9fxz, 9fyj - hGAL-8 N-terminal CRD + galactal ligand
  • 3ap8, 3vko - hGAL-8 N-terminal CRD + polysaccharide
    
  • 4gxl - hGAL-8 C-terminal CRD + NDP52 peptide
    
  • 4han - hGAL-8 N-terminal CRD+C-terminal CRD + NDP52 peptide
    
  • 4fqz – hGAL-8 N-terminal CRD+C-terminal CRD (mutant) + glucose + BGAL
    
  • 2yv8, 5gzc, 5gzd, 5gze, 5gzf, 5gzg, 5t7u – hGAL-8 N terminal CRD
    
  • 3ojb, 8hl9 - hGAL-8 C terminal CRD
    
  • 2yxs, 4bmb – hGAL-8 N terminal CRD + lactose
    
  • 4bme, 5t7s – hGAL-8 N terminal CRD (mutant) + lactose
    
  • 5t7i – hGAL-8 N terminal CRD + LNNT
    
  • 5t7t – hGAL-8 N terminal CRD (mutant) + LNT
    
  • 2yy1 – hGAL-8 N terminal CRD + acetyllactosamine
    
  • 5vwg, 6w4z – hGAL-8 N terminal CRD (mutant) + galactopyranoside derivative
    
  • 6z6y – hGAL-8 N terminal CRD + sulfatide
    
  • 7aen – hGAL-8 N terminal CRD + galactopyranoside derivative
    
  • 7p11, 7p1m – hGAL-8 N terminal CRD + galactose derivative
    
  • 4wvv, 4wvw - cGAL-8 N terminal CRD + lactose derivative
    
• Galectin-9; Domains – N-terminal CRD 1-148; C-teminal CRD 186-323
  • 3lsd – hGAL-9 N terminal CRD
    
  • 3wv6 – hGAL-9 N-terminal CRD+C-terminal CRD (mutant)
    
  • 3nv1 – hGAL-9 C terminal CRD
    
  • 3lse – hGAL-9 N terminal CRD + lactose
    
  • 2eak, 3wlu - hGAL-9 CRD + lactose
    
  • 3nv4 - hGAL-9 C-terminal CRD + sialyllactose
    
  • 2zhk, 2zhl, 2zhm, 2zhn, 3nv2 - hGAL-9 N-terminal CRD + acetyllactosamine
    
  • 3nv2 - hGAL-9 C-terminal CRD + acetyllactosamine
    
  • 3nv3 - hGAL-9 C-terminal CRD + polysaccharide
    
  • 2eal - mGAL-9 N-terminal CRD + pentasaccharide
    
  • 2d6k, 2d6l – mGAL-9 N-terminal CRD
    
  • 2d6m – mGAL-9 N-terminal CRD + lactose
    
  • 2d6n, 2d6o– mGAL-9 N-terminal CRD + acetyllactosamine
    
  • 2d6p – mGAL-9 N-terminal CRD + antigen
    
• Galectin-10; Residues 1-142
  • 5xrg, 5xrh, 6gks, 6gkq – hGAL-10
    
  • 5yt4, 5xri, 5xrj, 5xrk, 5xrl, 5xrm, 5xrn, 5xro, 5xrp, 6gkt, 6a1s, 6a1u, 6a1v, 6a1x, 6a1y, 8yqa, 8yqb, 8yqc – hGAL-10 (mutant)
    
  • 1bkz – hGAL-10 + mannose
    
  • 1hdk – hGAL-10 + PCMBS
    
  • 6a1t – hGAL-10 (mutant) + lactose
    
  • 5xrh, 6qrn – hGAL-10 + ribose
    
  • 6glw, 6glx, 6gku – hGAL-10 + antibody
    
  • 6l64, 6l67, 6l68, 6l6a, 6l6b, 6l6c, 6l6d – hGAL-10 + monosaccharide
    
  • 8jae – hGAL-10 (mutant) + trisaccharide
    
• Galectin-11
  • 6n3r – sGAL-11 + galactose - sheep
    
  • 6n44 – sGAL-11 + glycerol
    
• Galectin-13 or galactoside-binding soluble lectin 13
  • 5xg7 – hGAL-13
    
  • 5y03, 5xg9, 6a65, 6a66, 5xg8, 6kjw, 6kjx, 6kjy – hGAL-13 (mutant)
    
  • 6a62, 6a63, 6a64 – hGAL-13 (mutant) + lactose
    
  • 7cyb – smGAL-13 – squirrel monkey
    
  • 7cya – smGAL-13 + lactose
    
• Galectin-14
  • 6k2y – hGAL-14
    
  • 6k2z – hGAL-14 + lactose
    
• Galectin-16
  • 6ljp – hGAL-16
    
  • 6ljq, 6ljr – hGAL-16 (mutant) + lactose
    
• Galectin
  • 5nld, 5nle, 5nlh, 5nlz, 5nm1, 5nm6, 5nmj – cGAL + lactose
    
  • 3wuc, 3wud – GAL – frog
    
  • 1ww7 – AcGAL – Agrocybe cylindracea
    
  • 3wg2 – AcGAL (mutant)
    
  • 1ww4, 1ww5, 1ww6, 3wg1, 5xfd – AcGAL + lactose derivative
    
  • 3wg3, 3wg4 - AcGAL + tetraose
    
  • 4agg, 4agr, 4agv – GAL - Cinachyrella
    
  • 4hl0, 5glt, 5glu, 5glv, 5glw, 5glz, 5gm0, 8yzq – TlGAL – Toxascaris leonina
    
  • 8zqi – TlGAL (mutant) + glucose
    
  • 8hgj – TlGAL + mucin-3
    

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Michal Harel, Joel L. Sussman