| Structural highlights
Function
AGRD1_HUMAN Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701).[1] [2] [3]
References
- ↑ Bohnekamp J, Schöneberg T. Cell adhesion receptor GPR133 couples to Gs protein. J Biol Chem. 2011 Dec 9;286(49):41912-41916. PMID:22025619 doi:10.1074/jbc.C111.265934
- ↑ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X. Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett. 2012 Apr 24;586(8):1214-9. doi: 10.1016/j.febslet.2012.03.014. Epub, 2012 Mar 21. PMID:22575658 doi:https://dx.doi.org/10.1016/j.febslet.2012.03.014
- ↑ Bayin NS, Frenster JD, Kane JR, Rubenstein J, Modrek AS, Baitalmal R, Dolgalev I, Rudzenski K, Scarabottolo L, Crespi D, Redaelli L, Snuderl M, Golfinos JG, Doyle W, Pacione D, Parker EC, Chi AS, Heguy A, MacNeil DJ, Shohdy N, Zagzag D, Placantonakis DG. GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth. Oncogenesis. 2016 Oct 24;5(10):e263. PMID:27775701 doi:10.1038/oncsis.2016.63
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