9jjb | pdb_00009jjb

Class 1 state of the GfsA KSQ-ancestralAT chimeric didomain in complex with the GfsA ACP domain

spinqualitylabelsall models 9jjb, resolution 2.68Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9jjb is a 4 chain structure with sequence from Streptomyces graminofaciens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.68Å Ligands: 9EF Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GFSA_STRHA First protein in the synthesis of the 16-membered macrolide antibiotics FD-891 and FD-892 (PubMed:20589823). Composed of 5 modules; the first is a loading module (LM) that synthesizes a starter unit used by the first elongation module for polyketide chain elongation (PubMed:34985877, PubMed:37216195). The starter unit is extended by multiple rounds of addition of malonyl-CoA or methylmalonyl-CoA, and other modifications to help generate the final products (Probable) (PubMed:20589823). The loading module (residues 1-927, LM with an inactive acyltransferase domain) preferentially decarboxylates malonyl-GfsA acyl carrier protein of the LM (ACP-LM) over methylmalonyl-GfsA ACP-LM and has no activity on malonyl-CoA or methymalonyl-CoA (PubMed:34985877). LM decarboxylates malonyl-ACP-LM better than the malonyl-ACP-1 module of GfsA (i.e. the next module in the same protein) and has no activity on other malonyl-ACP modules (PubMed:37216195).

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