6l71 | pdb_00006l71

Sirtuin 2 demyristoylation native intermediate I & II mixture

spinqualitylabelsall models 6l71, resolution 2.11Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6l71 is a 2 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.109Å Ligands: NCA, YDD, YOY Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SIR2_HUMAN NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. See Also Histone deacetylase 3D structures

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