7v62 | pdb_00007v62

Crystal structure of human OSBP ORD in complex with cholesterol

spinqualitylabelsall models 7v62, resolution 3.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7v62 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.25Å Ligands: CIT, CLR, DMS, DTT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function OSBP1_HUMAN Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.

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