| Structural highlights
Function
TEKT4_MOUSE Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (PubMed:37295417, PubMed:37865089, PubMed:37989994). Contributes to normal sperm motility (PubMed:17244819).[1] [2] [3] [4]
References
- ↑ Roy A, Lin YN, Agno JE, DeMayo FJ, Matzuk MM. Absence of tektin 4 causes asthenozoospermia and subfertility in male mice. FASEB J. 2007 Apr;21(4):1013-25. PMID:17244819 doi:10.1096/fj.06-7035com
- ↑ Zhou L, Liu H, Liu S, Yang X, Dong Y, Pan Y, Xiao Z, Zheng B, Sun Y, Huang P, Zhang X, Hu J, Sun R, Feng S, Zhu Y, Liu M, Gui M, Wu J. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell. 2023 Jun 22;186(13):2897-2910.e19. PMID:37295417 doi:10.1016/j.cell.2023.05.009
- ↑ Chen Z, Shiozaki M, Haas KM, Skinner WM, Zhao S, Guo C, Polacco BJ, Yu Z, Krogan NJ, Lishko PV, Kaake RM, Vale RD, Agard DA. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Cell. 2023 Oct 19:S0092-8674(23)01038-3. PMID:37865089 doi:10.1016/j.cell.2023.09.017
- ↑ Tai L, Yin G, Huang X, Sun F, Zhu Y. In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov. 2023 Nov 21;9(1):116. PMID:37989994 doi:10.1038/s41421-023-00606-3
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