Insulin receptor 3D structures

3D structures of insulin receptor

Updated on 22-September-2025

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• Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310; Ectodomain 28-1382
  • 8u4b – hIR – human – Cryo EM
    
  • 1irk – hIR TK domain
    
  • 1i44, 1p14, 8dwn – hIR TK domain (mutant)
    
  • 2hr7 – hIR domains 1-3
    
  • 4xst – hIR L1-CR domains
    
  • 2mfr, 7pht – hIR transmembrane domain - NMR
    
• Insulin receptor complexes
  • 5j3h – hIR L1-CR domains + antibody + peptide
    
  • 7kd6 – hIR L1-CR domains + Scfv
    
  • 4xss – hIR L1-CR domains + insulin-like growth factor 1
    
  • 3w12 – hIR L1-CR domain + insulin + antibody
    
  • 3w13, 3w11 – hIR L1-CR domain + insulin + antibody + hIR a-CT peptide
    
  • 4xlv - hIR TK domain (mutant) + ATP derivative
    
  • 1ir3 - hIR TK domain (mutant) + ATP analog + peptide
    
  • 3bu5, 3bu6 - hIR TK domain + ATP + peptide
    
  • 3bu3 - hIR TK domain + peptide
    
  • 8dtl, 8dtm - hIR ectodomain + peptide – Cryo EM
    
  • 1gag, 2z8c - hIR TK domain (mutant) + peptide
    
  • 3ekk, 3ekn, 4ibm, 5hhw - hIR TK domain (mutant) + inhibitor
    
  • 3eta, 5e1s - hIR TK domain + inhibitor
    
  • 4zxb - hIR ectodomain (mutant) + antibody
    
  • 2auh – hIR TK domain + growth factor receptor-bound protein 14
    
  • 2b4s - hIR TK domain + tyrosine-protein phosphatase
    
  • 1rqq – hIR TK domain (mutant) + adaptor protein PS
    
  • 6ce7, 6ce9, 6ceb – hIR + insulin
    
  • 6pxv, 6pxw, 6sof, 7bw7, 7bw8, 7bwa, 7md4, 7md5, 7mqo, 7mqr, 7mqs, 7qid, 8guy, 8yyl, 8yys, 8yyt – hIR ectodomain + insulin – Cryo EM
    
  • 8eyx – hIR ectodomain (mutant) + insulin – Cryo EM
    
  • 7u6d, 7u6e – hIR ectodomain + agonist – Cryo EM
    
  • 7yq3, 7yq4, 7yq5, 7yq6 – hIR ectodomain + DNA – Cryo EM
    
  • 9jf9, 9jfd, 9jhs – hIR 28-946 + DNA – Cryo EM
    
  • 7pg0, 7pg2, 7pg3, 7pg4, 7sl1, 7sl2, 7sl3, 7sl4, 7sl6, 7sl7, 7sth, 7sti, 7stj, 7stk – hIR + insulin – Cryo EM
    
  • 8dtl, 8dtm – hIR + insulin mimetic – Cryo EM
    
  • 7s8v – hIR ectodomain + IGF-I receptor – Cryo EM
    
  • 8x06, 8x2m, 8xjs, 8xk1, 8xkm, 8xkr – hIR ectodomain + IGF-I – Cryo EM
    
  • 8u4c, 8u4e, 8vjc, 8ysz – hIR ectodomain + IGF-2 – Cryo EM
    
  • 7s0q – hIR ectodomain + IGF-I receptor + IGF-I – Cryo EM
    
  • 6hn4, 6hn5 - hIR + insulin
    
  • 5kqv – hIR + insulin + antibody
    
  • 6vep – hIR + insulin + antibody – Cryo EM
    
  • 8eyx, 8eyy, 8ez0 – mIR (mutant) + insulin – Cryo EM
    
  • 6veq – IR + insulin + antibody – Conus geographus - Cryo EM
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel