Isocitrate dehydrogenase 3D structures

3D Structures of Isocitrate dehydrogenase

Updated on 06-October-2025

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• Isocitrate dehydrogenase
  • 6kdf – hIDH3 α,β subunits - human
    
  • 8grb, 8gs5 – hIDH3 a (mutant),b subunits
    
  • 6kde – hIDH3 a,b subunits + Ca
    
  • 8grg – hIDH3 a,g subunits
    
  • 5grh – hIDH3 α,γ subunits + Mg
    
  • 7ce3 – hIDH3 α,β,γ subunits
    
  • 3blx – yIDH - yeast
    
  • 2uxq – DpIDH – Desulfotalea psychrophila
    
  • 3dms – IDH – Burkholderia pseudomallei
    
  • 2dht, 2e0c - StIDH – Sulfolobus tokodaii
    
  • 2iv0 – IDH – Archaeoglobus fulgidus
    
  • 1zor – IDH – Thermotoga maritima
    
  • 2b0t – IDH – Corynebacterium glutamicum
    
  • 1v94, 1xgv - ApIDH – Aeropyrum pernix
    
  • 1pb3, 1sjs, 3icd, 6icd, 7icd – EcIDH – Escherichia coli
    
  • 1idd, 1idf, 4icd - EcIDH (mutant)
    
  • 3ah3 – TtIDH – Thermus thermophilus
    
  • 3us8 – IDH – Sinorhizobium meliloti
    
  • 4aoy – CtIDH – Clostridium thermocellum
    
  • 5z16 – IDH – Acinetobacter baumannii
    
  • 5m2e - PaIDH – Pseudomonas aeruginosa
    
  • 6ixl – OtIDH – Ostreococcus tauri
    
  • 6lkz – IDH – Phaeodactylum tricomutum
    
  • 6ltf, 6m3s – IDH – Xanthomonas campestris
    
  • 7y1u – IDH – Campylobacter corcagiensis
    
• IDH+citrate
  • 5yfn – hIDH1 + isocitrate+ Mg
    
  • 5gri – hIDH3 α,γ subunits + citrate+ Mg
    
  • 8grh – hIDH3 a (mutant),g subunits + citrate
    
  • 1lwd – IDH+isocitrate+Mn - pig
    
  • 5h3f – mIDH 2 + isocitrate
    
  • 5h3e – mIDH 2 (mutant) + isocitrate
    
  • 2qfw – yIDH+isocitrate
    
  • 3blv – yIDH+citrate
    
  • 2uxr – DpIDH+isocitric acid
    
  • 1itw – AvIDH+isocitrate+Mn – Azotobacter vinelandii
    
  • 1p8f, 1pb1 – EcIDH+isocitrate
    
  • 1cw7, 5icd, 8icd - EcIDH +isocitrate+Mg
    
  • 1cw1 - EcIDH (mutant)+isocitrate+Mn
    
  • 1gro, 1grp, 4bnp - EcIDH (mutant)+isocitrate+Mg
    
  • 1hqs – IDH+citrate – Bacillus subtilis
    
  • 4zda - IDH +isocitrate+Mn – Mycobacterium smegmatis
    
  • 7e2w - OtIDH +isocitrate+Mg
    
• IDH+NADP
  • 1t09, 5yfm – hIDH+NADP
    
  • 3mar, 8vh9, 8vhc – hIDH1 (mutant) + NADP
    
  • 5k10, 5k11 – hIDH + NADP – Cryo EM
    
  • 5svn, 5svo – hIDH2 (mutant) + NADP
    
  • 6kdy, 6ke3 – hIDH3 α,β + NADH
    
  • 5yvt – hIDH α+γ + NADH
    
  • 5yzh – mIDH+NADP – mouse
    
  • 2qfv – yIDH+NADP
    
  • 2e5m – StIDH+NADP
    
  • 1tyo - ApIDH+NADP
    
  • 1j1w – AvIDH+NADP – Azotobacter vinelandii
    
  • 9icd - EcIDH +NADP
    
  • 1iso - EcIDH (mutant)+NAD
    
  • 3mbc - IDH (mutant)+NADP – Corynebacterium glutamicum
    
  • 4hcx, 5kvu – IDH + NADP – mycobacterium tuberculosis
    
  • 6aj6 – TbIDH (mutant) + NADP – Trypanosoma brucei
    
  • 6ixt – OtIDH + NAD + Mg
    
• IDH+α-ketoglutarate
  • 3inm, 4l03, 4l04, 4l06, 5i95, 8vha, 8vhb – hIDH1 (mutant)+NADPH+α-ketoglutarate+Ca
    
  • 4kzo - hIDH1 +NADPH+α-ketoglutarate+Ca
    
  • 2qfy - yIDH+α-ketoglutarate
    
  • 2qfx - yIDH+NADPH+α-ketoglutarate+Ca
    
  • 1cw4 – EcIDH (mutant)+α-ketoglutarate
    
  • 1ika - EcIDH + α-ketoglutarate+Ca
    
  • 4ajc - EcIDH (mutant) +α-ketoglutarate+A2P+Ca
    
  • 4ajr - EcIDH (mutant) +α-ketoglutarate+ NADP+ Mg
    
  • 1bl5 - EcIDH +α-ketoglutarate+NADP+Mg
    
  • 6c0e - IDH +NADPH+ α-ketoglutarate – Legionella pneumophila
    
  • 6g3u - PaIDH +NADPH+ α-ketoglutarate
    
  • 6aj8, 6aja, 6ajb - TbIDH (mutant) +NADP + α-ketoglutarate
    
• IDH binary complex with inhibitor
  • [8t7d]], 9b81 – hIDH + inhibitor
    
  • 6q6f, 8t7n, 8vhe – hIDH1 (mutant) + inhibitor
    
  • 3asj – TtIDH + inhibitor
    
• IDH higher complexes
  • 3map, 6pay - hIDH1 +NADP+isocitrate
    
  • 3mas, 8vhd – hIDH1 (mutant) +NADP+isocitrate
    
  • 1t0l – hIDH+NADP+isocitrate+Ca
    
  • 5gre, 5grf – hIDH3 α,γ subunits + ADP+ citrate+ Mg
    
  • 5grl – hIDH3 α,γ subunits + ADP+ isocitrate+ Mg
    
  • 5l57, 5l58 - hIDH1 +NADP + inhibitor
    
  • 4i3k, 4i3l, 4ja8,4umx, 4umy, 4xrx, 4xs3, 5de1, 5lge, 5sun, 5svf, 5tqh, 6adg, 6b0z, 6o2y, 6o2z, 6u4j, 6vei, 6vg0 - hIDH1 (mutant) +NADP + inhibitor
    
  • 8t7o - hIDH1 (mutant) +NADP + drug
    
  • 6bkx, 6bky, 6bkz, 6bl0, 6bl1, 6bl2 – hIDH1 + isocitrate + inhibitor
    
  • 6adi, 6vfz – hIDH2 (mutant) +NADP + inhibitor
    
  • 6l57, 6l59 – hIDH3 a+g + citrate + ATP
    
  • 8bay – hIDH1 (mutant) + NADP + butyloxoglutarate
    
  • 7pjn, 8hb9 – hIDH1 (mutant) +NADP + inhibitor
    
  • 8grd – hIDH3 a+b + ADP + Mg
    
  • 5svf - hIDH (mutant) +NADP + citrate + inhibitor
    
  • 5i96 – hIDH2 + NADP+ drug + Ca
    
  • 5yzi - mIDH+NADP+citrate
    
  • 8w49 - mIDH+NADP+ isocitrate
    
  • 8kib - mIDH+NADP+ oxaloacetate
    
  • 3blw – yIDH+citrate+AMP
    
  • 2d4v – IDH+NAD+citrate – Acidithiobacillus thiooxidans
    
  • 2d1c – TtIDH+NADP+citrate
    
  • 1xkd – ApIDH+NADP+citrate
    
  • 1idc - EcIDH (mutant)+oxalosuccinate+Mg
    
  • 6ajc - TbIDH (mutant) +NADP+isocitrate
    
  • 6ixn - OtIDH +NAD + citrate
    
• IDH quaternary complexes
  • 5svf, 6io0 – hIDH1 (mutant) +NADP + citrate + inhibitor
    
  • 8gru – hIDH1 (mutant) +NAD + isocitrate + Ca
    
  • 7pjm – hIDH1 (mutant) +NADP + oxoglutarate + Ca
    
  • 1hj6 – EcIDH (mutant)+NADP+isopropylmalate+Mg
    
  • 1ai3 - EcIDH +isocitrate+Mg+NDP
    
  • 1ai2, 4aj3, 4aja - EcIDH +isocitrate+NADP+Ca
    
  • 1ide, 4ajb - EcIDH (mutant)+isocitrate+Mg+NADP
    
  • 4ajs - EcIDH (mutant)+isocitrate+Mg+ A2P + NMN
    
  • 4p69 - EcIDH + IDH kinase/phosphatase + AMP + ADP
    
  • 3lcb - EcIDH + IDH kinase/phosphatase + AMP + ATP
    
  • 4aou - CtIDH + isocitrate+NADP+Mg
    
  • 4aov - DpIDH + isocitrate+NADP+Mg
    
  • 7e3n - TbIDH (mutant) +NADP + α-ketoglutarate + Ca
    

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