| Structural highlights
Function
TONSL_HUMAN Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.[1] [2] [3] [4]
References
- ↑ O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell. 2010 Nov 24;40(4):619-31. doi: 10.1016/j.molcel.2010.10.024. Epub 2010 , Nov 4. PMID:21055983 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.024
- ↑ Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010 Nov 24;40(4):632-44. doi: 10.1016/j.molcel.2010.10.023. Epub 2010 , Nov 4. PMID:21055984 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.023
- ↑ O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24;40(4):645-57. doi: 10.1016/j.molcel.2010.10.022. Epub 2010 , Nov 4. PMID:21055985 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.022
- ↑ Ray P, Zhang DH, Elias JA, Ray A. Cloning of a differentially expressed I kappa B-related protein. J Biol Chem. 1995 May 5;270(18):10680-5. PMID:7738005
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