9q3g | pdb_00009q3g

Cryo-EM structure of human AGO1 in complex with guide RNA

spinqualitylabelsall models 9q3g, resolution 3.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9q3g is a 2 chain structure with sequence from Homo sapiens and Trichoplusia ni. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.3Å Ligands: N Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function AGO1_HUMAN Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

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