Cyclophilin 3D structures

3D Structures of Cyclophilin

Updated on 06-November-2025

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• Cyclophilin-A or peptidyl-prolyl cis-trans isomerase A
  • 2x25, 2x2a, 3k0m, 3k0n, 1w8l, 1w8m, 1w8v, 1rmh, 2cpl, 5kv7, 5kv6, 5kv5, 5kv4, 5kv3, 5kv2, 5kv1, 5kv0, 5kuz, 5kuw, 5kuv, 5kuu, 5kus, 5kur, 5kuq, 5kuo, 5kun, 4kul, 5f66, 4yup, 4yuo, 4yun, 4yum, 4yul, 4yuk, 4yuj, 4yui, 4yuh, 4yug, 2n0t, 5kul, 6u5c, 6u5d, 6u5e, 6u5g – hCyp-A – human
    
  • 1oca, 2mzu, 7ta8 – hCyp-A - NMR
    
  • 3k0o, 3k0p, 3k0q, 3k0r, 2alf ,6bta, 5wc7, 7qbw – hCyp-A (mutant)
    
  • 4dgd - RmCyp-A (mutant) – Rhesus macaque
    
  • 6fk1 – mCyp-A – mouse
    
  • 4e1q – Cyp-A – wheat
    
  • 1ist – yCyp-A – yeast
    
  • 1w74 – Cyp-A – Mycobacterium tuberculosis
    
  • 3o7t – NpCyp-A – Noniliophthora perniciosa
    
  • 4eyv – Cyp-A – Piriformospora indica
    
  • 5ex2, 5ex1 – Cyp-A – Hirschia baltica
    
  • 7zfm - EcCyp-A - Escherichia coli
    
  • 7rfd - EcCyp-A (mutant)
    
  • 7a73 – Cyp-A – Anabaena
    
• Cyclophilin-A complex
  • 2a2c, 1cwa, 1cwb, 1cwc, 2x2c – hCyp-A+cyclosporin A
    
  • 3cys - hCyp-A+cyclosporin A - NMR
    
  • 1cwj, 1bck, 1cwi, 1cwo, 1cwf, 1cwh, 1cwk, 1cwl, 1cwm, 1mik, 5hsv - hCyp-A+cyclosporin A derivative
    
  • 2rma, 2rmb - hCyp-A+cyclosporin A+cyclosporin A derivative
    
  • 1mf8, 1m63 - hCyp-A+cyclosporin A+ calcineurin subunits A,B
    
  • 3odi, 3odl – hCyp-A+voclosporin
    
  • 2x2d, 1m9c, 1m9d, 1m9e, 1m9f, 1m9x, 1m9y, 1awq, 1awr, 1aws, 1awt, 1awu, 1awv, 1ak4, 1fgl - hCyp-A+HIV-1 N-terminal capsid domain
    
  • 5fjb - hCyp-A + HIV-1 gag protein
    
  • 6y9w, 6y9v, 6y9x, 6y9y, 6y9z, 6zdj - hCyp-A + HIV-1 gag protein – Cryo EM
    
  • 1zkf – hCyp-A+suc-AGPF-pNA
    
  • 1ynd, 1nmk, 5ta4, 5ta2, 5t9z, 5t9w, 5t9u, 9ghy – hCyp-A+ sanglifehrin derivaive
    
  • 4n1s, 4n1r, 4n1q, 4n1p, 4n1o, 4n1n, 4n1m, 3rdd, 5noz, 5noy, 5nox, 5nou, 5nov, 5now, 5nor, 5nos, 5not, 5noq, 5lud, 6gji, 6gjj, 6gjl, 6gjm, 6gjn, 6gjp, 6gjr, 6gjy, 6gs6, 6x3r, 6x3y, 6x4m, 6x4n, 6x4o, 6x4p, 6x4q – hCyp-A + inhibitor
    
  • 2cyh, 3cyh, 4cyh, 5cyh - hCyp-A+dipeptide
    
  • 1vbs, 1vbt, 2ms4, 7abt, 7pcj – hCyp-A+tetrapeptide
    
  • 6i42, 6j42 - hCyp-A + synuclein peptide
    
  • 7uxj, 7uxm, 7uxn - hCyp-A + polypeptide
    
  • 4ipz - hCyp-A (mutant) + peptide
    
  • 8g9p – hCyp-A + K-ras
    
  • 8g9q, 8tbf, 8tbh, 8tbj, 8tbk, 8tbl, 8tbm, 8tbn, 9ax6, 9bfy, 9bg1, 9bgh, 9bho, 9bhp, 9bhq – hCyp-A + K-ras + inhibitor
    
  • 9bi1 – hCyp-A + K-ras + inhibitor + AMPPNP
    
  • 9bi2 – hCyp-A + K-ras + inhibitor + GMPPNP
    
  • 8tbi – hCyp-A + N-ras + inhibitor
    
  • 8tbg – hCyp-A + H-ras + inhibitor
    
  • 7upn – hCyp-A + elongin B,C + visna virus infectivity factor – Cryo EM
    
  • 4ipz - hCyp-A (mutant) + peptide
    
  • 4dga, 4dgb, 4dgc - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant)
    
  • 4dge - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant)
    
  • 2xgy – Cyp-A+RELIK capsid N-terminal - rabbit
    
  • 1vdn – yCyp-A+peptidyl coumarin
    
  • 9cf0, 9cf1, 9cf2, 9cf3 – yCyp-A + MMBP + DNA + RNA – Cryo EM
    
  • 1lop - EcCyp-A+peptidyl nitroanilide - Escherichia coli
    
  • 1csa – EcCyp-A+ cyclosporin A – NMR
    
  • 8xck - EcCyp-A+ tip attachment protein J – Cryo EM
  • 3o7t – NpCyp-A – Noniliophthora perniciosa
    
  • 3pmp - NpCyp-A + cyclosporin A
    
  • 3t1u – Cyp-A + peptide – Azotobacter vinelandii
    
• Cyclophilin-B
  • 3ich – hCyp-B
    
  • 3ici - hCyp-B+calmegin fragment
    
  • 1cyn – hCyp-B +cyclosporin A derivative
  • 8k0f, 8k0i, 8k0m, 8k17, 8kc9 – hCyp-B + prolyl hydroxylase 3 + cartilage-associated protein – Cryo EM
    
  • 1cyn – hCyp-B +cyclosporin A derivative
    
  • 4fru – hoCyp-B – horse
    
  • 4frv – hoCyp-B (mutant)
    
  • 1a58, 4jcp – Cyp-B – Brugia malayi
    
  • 7q6p – EcCyp-B
    
  • 2rs4 – EcCyp-B - NMR
    
  • 1j2a, 7n3j – EcCyp-B (mutant)
    
  • 1v9t – EcCyp-B+peptidyl nitroanilide
    
  • 1vai - EcCyp-B+peptidyl coumarin
    
• Cyclophilin-C
  • 2esl - hCyp-C+cyclosporin A
    
  • 2rmc - mCyp-C+cyclosporin A
    
  • 1jns, 1jnt – EcCyp-C - NMR
    
• Cyclophilin-D or peptidyl-prolyl cis-trans isomerase F
  • 2bit, 3qyu, 9h0s, 6ybm – hCyp-D
    
  • 4zsd, 4o8h, 4o8i, 8uc4, 8uc5 - hCyp-D (mutant)
    
  • 2biu – hCyp-D+DMSO
    
  • 7r2h - hCyp-D (mutant) +DMSO
  • 2z6w - hCyp-D+cyclosporin A
    
  • 5a0e - hCyp-D (mutant) + cyclosporin A
    
  • 4tot – hCyp-D + polypeptide inhibitor
    
  • 9h0s, 6r8o, 6r8w, 6r9s, 6r9u, 6r9x, 6ra1 – hCyp-D + inhibitor
    
  • 3r49, 3r4g, 3r54, 3r56, 3r57, 3r59, 3rcf, 3rcg, 3rci, 3rck, 3rcl, 3rd9, 3rda, 3rdb, 3rdc, 4j58, 4j59, 4j5a, 4j5b, 4j5c, 4j5d, 5ccs, 5ccr, 5ccq, 5ccn, 5cbw, 5cbv, 5cbu, 5cbt, 4zsc, 4xnc, 4j5e, 6r8l, 7ogi, 7pmt, 7r2i, 7r2j, 7r2l, 7tgs, 7tgt, 7tgu, 7tgv, 7th1, 7th6, 7th7, 7thc, 7thd, 7thf, 7zdn, 8ejx – hCyp-D (mutant) + inhibitor
    
• Cyclophilin-E or peptidyl-prolyl cis-trans isomerase E or Cyp33
  • 1zmf, 2r99, 3uch – hCyp-E PPIASE domain 137-301
    
  • 2cqb, 3lpy, 3mdf – hCyp-E RRM domain 1-114
    
  • 2kyx, 7zev – hCyp-E RRM domain – NMR
    
  • 7zew, 7zex – hCyp-E RRM domain + RNA – NMR
    
  • 7zey – hCyp-E RRM domain + MLL1 zinc finger – NMR
    
  • 7zez – hCyp-E RRM domain + MLL1 zinc finger + histone H3 N-terminal – NMR
    
  • 7w5a, 8ch6, 8h6k, 8h6l – hCyp-E in spliceosome complex – Cryo EM
  • 2ck1, 2cmt – Cyp-E – Schistosoma mansoni
    
• Cyclophilin-G
  • 2wfi, 2gw2 - hCyp-G PPIASE domain
    
  • 2wfj - hCyp-G PPIASE domain+cyclosporin A
    
• Cyclophilin-H
  • 1mzw – hCyp-H+peptide
    
• Cyclophilin-J
  • 2ok3, 1xyh - hCyp-J
    
  • 2oju - hCyp-J+cyclosporin A
    
• Cyclophilin-PPI1
  • 8i0r – hCyp-PPI1 in Bact-I complex – Cryo EM
  • 8i0s – hCyp-PPI1 in Bact-II complex – Cryo EM
  • 8i0t – hCyp-PPI1 in Bact-III complex – Cryo EM
  • 7w59, 8i0p – hCyp-PPI1 in pre-Bact complex – Cryo EM
  • 8i0v – hCyp-PPI1 in post-Bact complex – Cryo EM
  • 9fmd – hCyp-PPI1 in spliceosome complex – Cryo EM
  • 9esh, 9esi – Cyp-PPI1 in spliceosome complex – fission yeast – Cryo EM
  • 8xi2 – Cyp-PPI1 in spliceosome complex – Chlamydomonas reinhardtii – Cryo EM
• Cyclophilin-3
  • 2igv, 2igw, 1e8k – CeCyp-3+dipeptide – Caenorhabditis elegans
    
  • 1dyw - CeCyp-3
    
  • 1e3b – CeCyp-3+AUP(ET)3
    
• Cyclophilin-5
  • 1h0p – CeCyp-5 (mutant)
    
• Cyclophilin-20-2
  • 7wff, 7wg5 – AtCyp-20-2 in electron transfer complex – Arabidopsis thaliana – Cryo EM
    
• Cyclophilin-38
  • 3rfy – Cyp-38
    
• Cyclophilin-40
  • 1ihg, 1iip – Cyp-40 – bovine
    
• Cyclophilin
  • 1qoi – hCyp SNUCYP-20
    
  • 2wlw - Cyp – macaca mulata
    
  • 2mc9 - Cyp – rosy periwinkle
    
  • 3bo7, 8b58, 8r7s, 8r7u - TgCyp+cyclosporin A - Toxoplasma gondii
  • 8r7t - TgCyp+ alisporivir
  • 2nul – EcCyp
    
  • 1clh – EcCyp – NMR
    
  • 3k2c – Cyp – Encephalitozoon cuniculi
    
  • 3eov - LdCyp+cyclosporin A – Leishmania donovani
    
  • 3bt8 – LdCyp
    
  • 6l2b – LdCyp (mutant)
    
  • 2haq – LdCyp-A
    
  • 2hqj – Cyp – Leishmania major
    
  • 3bkp – TgCyp
    
  • 2cfe – Cyp – Malassezia sympodialis
    
  • 2c3b – Cyp – Aspergillus fumigatus
    
  • 1z81 – Cyp – Plasmodium Yoelli
    
  • 1qng – PfCyp+cyclosporin A – Plasmodium falciparum
    
  • 1qnh – PfCyp (mutant)+cyclosporin A
    
  • 1xo7 – TcCyp – Trypanosoma cruzi
    
  • 1xq7 - TcCyp+cyclosporin A
    
  • 2ko7, 2l2s – BpCyp+inhibitor – Burkholderia pseudomallei
    
  • 2ke0, 3s6m – BpCyp – NMR
    
  • 4dz2, 4dz3 – BpPin1 (mutant) + FK506
    

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