9nmp | pdb_00009nmp

Structure of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; open pore)

spinqualitylabelsall models 9nmp, resolution 3.09Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9nmp is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.09Å Ligands: A1BYZ, ATP, CA, CFF, PCW, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function FKB1A_MOUSE Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

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