User:Akash Bhadra/Structural Analysis and Development of Notum Fragment Screening Hits

Introduction

spinqualitylabelsall models Notum crystallized with fragment 718 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Wnt signalling is implicated in processes involved in animal embryonic development, adult tissue homeostasis, and regeneration. As the enzyme Notum can render Wnt inactive, it is a biologically and medically important target. In Structural Analysis and Development of Notum Fragment Screening Hits, the authors aim to discover small-molecule inhibitors of Notum, which suppresses Wnt signaling by removing a lipid modification from Wnt proteins. Biological role of the Wnt pathway Wnt ligands initiate signaling by binding Frizzled receptors and LRP co-receptors, stabilizing β-catenin and allowing transcriptional programs that control cell proliferation and differentiation. This process is fundamental for normal development and tissue homeostasis, and disruption of Wnt signaling contributes to numerous diseases.

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Akash Bhadra