10nh | pdb_000010nh

Crystal Structure of Apurinic endonuclease (APN1) from Babesia bovis

spinqualitylabelsall models 10nh, resolution 2.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 10nh is a 6 chain structure with sequence from Babesia bovis T2Bo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.65Å Ligands: HEZ, IMD, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function S6B9Y3_BABBO Plays a role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress. Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) with a preference for C as opposite base. Has 3'-phosphatase activity; removes 3'-phosphate from blunt-end, recessed, and gapped DNA templates and thus, removes 3'-blocks for DNA polymerase activity during BER. Lacks 3'-5' exonuclease activity and does not cleave damaged bases by nucleotide incision repair (NIR).[ARBA:ARBA00054483]

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