9j5k | pdb_00009j5k

Pathogen effector forms a phosphatase holoenzyme complex with host core enzyme to promote disease

spinqualitylabelsall models 9j5k, resolution 3.39Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9j5k is a 8 chain structure with sequence from Actinomycetaceae, Arabidopsis thaliana, Homo sapiens and Phytophthora sojae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.39Å Ligands: MN, TPO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PP2AA_HUMAN PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.

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