Neuraminidase 3D structures

3D structures of Neuraminidase

Updated on 24-March-2026

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• Neuraminidase
  • 1snt, 1so7 – hNeu2 - human
    
  • 2f24, 2f26, 2f28 – hNeu2 (mutant)
    
  • 8du5 – mNeu1 - mouse
    
  • 2vvz, 2w20, 2ya4 – SpNANA catalytic domain – Streptococcus pneumoniae
    
  • 3h71 - SpNANA catalytic domain precursor
    
  • 4zxk - SpNANA carbohydrate-binding domain
    
  • 4yw4, 4yz4 – SpNANC
    
  • 2xcy, 2xzi, 2xzj, 2xzk – NANA – Aspergillus fumigatus
    
  • 2w68 – VcNANA sialic acid binding domain – Vibrio cholerae
    
  • 1kit, 1w0o – VcNANA
    
  • 1eur - MvNANA residues 43-407 – Micromonospora viridifaciens
    
  • 1euu - MvNANA residues 47-647
    
  • 1w8n, 1w8o, 1wcq, 2hu0, 2hu4 – MvNANA residues 47-647 (mutant)
    
  • 3sil, 6trg, 7af2– StNANA (mutant) – Salmonella typhimurium
    
  • 4bbw, 5muk – BtNAN – Bacterioides thetaiotaomicron
    
  • 5tsp - NANI + CHES – Clostridium perfringens
    
  • 6mrx - baNANA - bacterium
    
• Binary complexes
  • 2f0z, 2f10, 2f11, 2f12, 2f13 – hNeu2 + inhibitor
    
  • 2f25, 2f27, 2f29, 4nc5, 4ncs - hNeu2 (mutant) + sialic acid analog
    
  • 1vcu - hNeu2 + sialic acid analog
    
  • 3h72 - SpNANA catalytic domain precursor + sialic derivative
    
  • 3h73 - SpNANA catalytic domain precursor + sialic acid analog
    
  • 2ya5 - SpNANA catalytic domain + sialic acid
    
  • 2ya7, 2ya8, 5f9t, 5kky - SpNANA catalytic domain + inhibitor
    
  • 2ya6- SpNANA catalytic domain + sialic acid analog
    
  • 4yw1, 4wy2, 4wy3, 4yz2 – SpNANC + inhibitor
    
  • 4yw1 – SpNANC residues 83-740 + sialic acid + neuraminic acid derivative
    
  • 4yw5, 4yz3 – SpNANC + drug
    
  • 6eks, 6eku – VcNANC + drug
    
  • 1w0p – VcNANA + sialic derivative
    
  • 1eus - MvNANA residues 43-407 + neuraminic acid derivative
    
  • 2bzd - MvNANA residues 47-647 (mutant) + galactose
    
  • 1eut - MvNANA residues 47-647 + galactose
    
  • 2ber - MvNANA residues 47-647 (mutant) + sialic derivative
    
  • 1dil, 1dim – StNANA + inhibitor
    
  • 2sil, 2sim, 7aey - StNANA + neuraminic acid derivative
    
  • 6tvi - StNANA (mutant) + neuraminic acid derivative
    
  • 5mul – BtNAN + glucuronic acid
    
  • 6myv - baNANA + neuraminic acid derivative
    
• Influenza virus neuraminidase
  • 1nn2, 1v0z, 2b8h, 2cml, 2ht5, 3beq, 3cye, 3k36, 3nss, 4hzv, 4fvk, 4gez, 9gqt, 9gqx – IvNANA residues 82-469 – Influenza virus
    
  • 4fvk, 4gez - IvNANA residues 76-442
    
  • 3k38, 4hzy – IvNANA (mutant)
    
  • 4b7m, 6d96, 7s0i - IvNAN H1n1
    
  • 7u2q, 7u2t - IvNAN – Cryo EM
    
  • 4cpl, 4cpn, 4cpo - IvNAN
    
  • 6n4d, 7u4e, 7u4f, 7u4g, 9mqw – IvNAN H3n2
    
  • 9cyg, 9ijv – IvNAN H3n2 – Cryo EM
    
  • 4qn4 – IvNAN H3n6
    
  • 4wa3 – IvNAN H3n8
    
  • 2ht5, 2htv, 2hty, 5hug – IvNAN H5n1
    
  • 9l44 – IvNAN H5n1 – Cryo EM
    
  • 5huk – IvNAN H5n2
    
  • 5hum, 5hun – IvNAN H5n6
    
  • 3nn9, 4mwj, 4mwl, 4nn9, 5l14, 5nn9, 6nn9 – IvNAN H7n9
    
  • 6pzd – IvNAN H7n9 (mutant)
    
  • 4qn3 – IvNAN H10n7
    
  • 6mcx, 7nn9 - IvNAN H11n9 Tern
    
  • 3sal - IvNAN H12n5 residues 82-469
    
  • 4gdi, 4gdj - IvNAN H17n10
    
  • 4mc7 – IvNAN H18n11
    
  • 2hty, 9gqq - IvNAN N1 residues 82-469
    
  • 9ewq - IvNAN N1 residues 82-469 – Cryo EM
    
  • 4gzo, 4k1h, 4k1i, 4k1k - IvNAN N2 residues 77-469
    
  • 4gzs, 4k1j - IvNAN N2 residues 77-469 (mutant)
    
  • 2htv - IvNAN N4 residues 82-469
    
  • 6hgb – IvNAN N6
    
  • 2ht5 – IvNAN N8 residues 82-469
    
  • 6hfc, 6d3b – IvNAN N9
    
  • 7nn9 - IvNAN N9 Tern
    
  • 2qwa - IvNAN N9 Tern (mutant)
    
  • 6crd - IvNAN N9 Tern/tetrabrachion
    
  • 7cm1, 7fgb, 7fgc, 7fgd, 7fge - IvNAN - toad
    
  • 7xvr, 7xvu, 7xvv, 7xvw - IvNAN - eel
    
• Binary complexes of Influenza virus neuraminidase
  • 1nsb, 1nsc, 1nsd, 1w1x, 1w20, 1w21, 2c4a, 2c4l, 3o9j, 3o9k – IvNANA + sialic derivative
    
  • 1a4g, 1a4q, 1b9s, 1b9t, 1b9v, 1f8c, 1f8d, 1f8e, 1inf, 1ing, 1inh, 1ivb, 1ivc, 1ivd, 1ive, 1ivf, 1ivg, 1l7f, 1vcj, 3b7e, 3k37, 4d8s, 4ks1, 4ks2, 4ks3, 4ks4, 4ks5, 4m3m, 4mju, 4mjv – IvNANA + inhibitor
    
  • 1l7g, 1l7h, 3ckz, 3cl0, 3cl2, 3k39, 3k3a - IvNANA (mutant) + inhibitor
    
  • 1f8b, 1inv, 1inw, 1inx, 1iny, 4gb1 – IvNANA + sialic acid analog
    
  • 3ti3, 3ti4, 3ti5, 3ti6, 6g01, 6g02 – IvNAN H1n1 + inhibitor
    
  • 4qnp, 6lxi, 6lxk, 6q23 - IvNAN H1n1 + antibody
    
  • 8e6j, 8e6k, 8ez8, 8g30, 8g3m, 8g3n, 8g3o, 8g3p, 8g3q, 8g3r, 8g3v, 8g3z, 8g40, 8u1c, 8u1q, 8u1s, 8yvl, 8zr4, 9cye, 9cyh, 9dpc, 9eje, 9ejf, 9kod, 9md2, 9md3, 9md5, 9md6, 9o4n, 9o4o, 9o4p, 9o4q, 9o9v - IvNAN H1n1 + antibody – Cryo EM
    
  • 9fm2 - IvNAN H1n1 + Vhh – Cryo EM
    
  • 3tia, 3tib, 3tic – IvNAN H2n2 + inhibitor
    
  • 6q20 - IvNAN H2n2 + antibody
    
  • 6n6b, 9mqv - IvNAN H3n2 + antibody
    
  • 8ez3, 8ez7, 8gat, 8gau, 8gav, 8yvm, 8yvn, 8zyx, 9cyf, 9cyi, 9cyj, 9osr - IvNAN H3n2 + antibody – Cryo EM
    
  • 2bat, 4gzq, 4gzw, 4gzx, 8dwb – IvNAN H3n2 + sialic acid
    
  • 2ht7, 2ht8, 2htq, 2htu – IvNAN H5n1 + inhibitor
    
  • 2htr, 2htw – IvNAN H5n1 + sialic acid analog
    
  • 8z4e - IvNAN H5n6 + scFv – Cryo EM
    
  • 5l18 - IvNAN H7n9 + sialic acid
    
  • 6lxj, 6q1z, 6pzf, 6pzw, 6pzy, 6pzz - IvNAN H7n9 + antibody
    
  • 6u02 - IvNAN H7n9 + antibody – Cryo EM
    
  • 6pze - IvNAN H7n9 (mutant) + antibody
    
  • 6v4n, 6v4o - IvNAN + antibody – Cryo EM
    
  • 8yvk - IvNAN H10n4 + antibody – Cryo EM
    
  • 9eit - IvNAN H10n5 + antibody – Cryo EM
    
  • 1nna, 1nnb, 5w26, 5w2u, 5w2w, 5w2y - IvNAN H11n9 + neuraminic acid derivative
    
  • 4dgr - IvNAN H11n9 + benzoic acid derivative
    
  • 4weg - IvNAN H11n9 + sialic acid derivative
    
  • 1bji, 1nnc - IvNAN H11n9 Tern + sialic acid analog
    
  • 1xoe, 1xog, 3w09 - IvNAN H11n9 Tern + inhibitor
    
  • 4qn5 - IvNAN H12n5 + sialic acid
    
  • 4h52, 4h53 – IvNAN N2 + inhibitor
    
  • 2qwb - IvNAN N9 Tern (mutant) + sialic derivative
    
  • 2qwc, 2qwd, 2qwe - IvNAN N9 Tern (mutant) + sialic acid analog
    
  • 1mwe - IvNAN N9 Tern + sialic acid
    
  • 2qwf, 2qwg, 2qwh, 2qwi, 2qwj, 2qwk - IvNAN N9 Tern (mutant) + inhibitor
    
  • 1a14, 1nca, 1ncb, 1ncc, 1ncd, 1nma, 1nmb, 1nmc, 2aep, 2aeq - mIvNAN N9 Tern + antibody
    
• Binary complexes of Influenza virus neuraminidase with drug
  • 4b7j, 4b7n, 4b7q, 4b7r, 4cpm, 4cpy, 4cpz, 5nzn, 6hp0, 9hlg, 9hlh, 9hli - IvNAN H1n1 + drug
    
  • 5nwe, 5nz4, 5nze, 5nzf - IvNAN H1n1 (mutant) + drug
    
  • 4gzp, 4gzt, 6br5, 6br6 - IvNAN H3n2 + drug
    
  • 4qn6 - IvNAN H3n6 + drug
    
  • 4wa4, 4wa5 - IvNAN H3n8 + drug
    
  • 4mwq, 4mwr, 4mwu, 4mwv, 4mww, 4mwx, 4mwy, 4mx0, 5jyy, 5l15, 5l17 - IvNAN H7n9 + drug
    
  • 4mwq, 4mwr, 4mwu, 4mwv, 4mww, 4mwx, 4mwy, 4mx0 - IvNAN H7n9 + flu drug
    
  • 4qn7- IvNAN H10n7 + drug
    
  • 3san, 3ti8, 7e6q - IvNAN H12N5 + flu drug
    
  • 4hzw, 4hzx - IvNAN N3 + flu drug
    
  • 4hzz, 4i00 - IvNAN N3 (mutant) + flu drug
    
  • 3san, 3ti8 - IvNAN N5 + flu drug
    
  • 6hg5 - IvNAN N6 + flu drug
    
  • 6hfy - IvNAN N6 + neuraminic acid derivative
    
  • 6heb, 6hcx - IvNAN N9 + flu drug
    
  • 6hg0 - IvNAN N9 Tern + NANA
    
• Endo-neuraminidase
  • 3gvf, 3gvj , 3gvk – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F
  • 3gvl, 3ju4 – ENANA residues 246-910
  • 3gw6 – ENANA residues 790-1064
• Pseudaminidase
  • 2w38, 3h6j – PNANA – Pseudomonas aeruginosa
• Trans-sialidase
  • 1sli, 2sli, 3sli – lTS + inhibitor – leech
  • 1mr5, 1ms3, 1ms4 - TcTS (mutant) – Trypanosoma cruzi
    
  • 1ms0 - TcTS (mutant) + neuraminic acid derivative + lactose
    
  • 1ms1, 1ms8 - TcTS (mutant) + neuraminic acid derivative
    
  • 3b69 - TcTS (mutant) + NANA derivative
    
  • 1ms5 - TcTS (mutant) + Na-S-Gal
    
  • 1ms9, 3pjq - TcTS (mutant) + lactose
    
  • 1s0i - TcTS (mutant) + sialyl-lactose
    
  • 1s0j - TcTS (mutant) + MUNANA
    
  • 3opz - TcTS (mutant) + antibody
    
  • 2ah2 - TcTS (mutant) + difluorosialic acid
    
• Neuraminidase B or sialidase B
  • 2vw0, 2vw1, 2vw2 – SpNANB
    
  • 4xhb, 4xik, 4xio, 4xjz, 4xmi - SpNANB (mutant)
    
  • 4foq, 4fov, 4fow, 4foy, 4fp2, 4fp3, 4fpc, 4fpe, 4fpf, 4fpg, 4fph, 4fpj, 4fpk, 4fpl, 4fpo, 4fpy, 4fq4, 4xe9, 4xhx, 4xil, 4xj9, 4xja, 4xju, 4xjw, 4xma - SpNANB (mutant) + inhibitor
    
  • 4xog - SpNANB (mutant) + neuraminic acid derivative + inhibitor
    
  • 2jkb, 4xj8 - SpNANB residues 30-697 + sialic acid analog
    
  • 4c1w - SpNANB residues 52-236 + sialic acid derivative
    
  • 4xyx – SpNANB + drug
    
  • 4yw2 – SpNANB residues 83-740 + sialic acid
    

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Michal Harel