Structural highlights
9nq5 is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.74Å |
| Ligands: | CL, DMS, EDO, EPE, GOL, K, LLP, NA, ORD, PMP, PUT |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
DOKDC_SALTY Catalyzes the decarboxylation of D-ornithine and D-lysine (PubMed:29024617, PubMed:30699288). Ornithine is likely the physiological substrate (PubMed:29024617). Has no detectable diaminopimelate decarboxylase activity in vitro (PubMed:29024617).[1] [2]
References
- ↑ Phillips RS, Poteh P, Miller KA, Hoover TR. STM2360 encodes a d-ornithine/d-lysine decarboxylase in Salmonella enterica serovar typhimurium. Arch Biochem Biophys. 2017 Nov 15;634:83-87. doi: 10.1016/j.abb.2017.09.010. Epub, 2017 Oct 9. PMID:29024617 doi:https://dx.doi.org/10.1016/j.abb.2017.09.010
- ↑ Phillips RS, Poteh P, Krajcovic D, Miller KA, Hoover TR. Crystal Structure of d-Ornithine/d-Lysine Decarboxylase, a Stereoinverting Decarboxylase: Implications for Substrate Specificity and Stereospecificity of Fold III Decarboxylases. Biochemistry. 2019 Feb 26;58(8):1038-1042. doi: 10.1021/acs.biochem.8b01319. Epub, 2019 Feb 1. PMID:30699288 doi:https://dx.doi.org/10.1021/acs.biochem.8b01319
