3D structures of hypoxia-inducible factor

3D structures of hypoxia-inducible factor

Updated on 29-March-2026

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• HIF-1α; Human domains – PAS-B 238-348; CTAD (C-terminal activation) 776-826;
  • 1l8c – hHIF-1 CTAD + CREB-binding protein – human – NMR
    
  • 1h2k, 1h2l, 1h2m, 2ilm, 3d8c – hHIF-1 CTAD + FIH-1
    
  • 1l3e – hHIF-1 CTAD + P300
    
  • 4zpr – hHIF-1 + ARNT + DNA
    
  • 9of0, 9of2, 9ofu – hHIF-1 + ARNT + DNA – Cryo EM
    
  • 4h6j – hHIF-1 PAS-B (mutant) + ARNT
    
• HIF-1β or aryl hydrocarbon receptor nuclear translocator (ARNT); C-terminal PAS 345-470
  • 2b02, 4eq1 – hARNT PAS-B
    
  • 1x0o, 2hv1, 2k7s – hARNT C-terminal PAS - NMR
    
  • 5ufp – hARNT C-terminal PAS + HIF-2 peptide
    
  • 4pky – hARNT C-terminal PAS + HIF-2 peptide + ARNT-interacting protein
    
  • 4lpz – hARNT C-terminal PAS + coactivator
    
  • 8g4a – hARNT C-terminal PAS + tetrazole derivative
    
  • 8k71, 8k72, 8k73 – hARNT C-terminal PAS + thiazole derivative
    
  • 4gs9 – hARNT C-terminal PAS (mutant) + HIF-2 peptide
    
  • 5tbm – hARNT C-terminal PAS + EPAS-1
    
  • 5v0l – hARNT 70-345 + mAHR + DNA
    
  • 4zp4, 4zpk – mARNT + mHIF-2 - mouse
    
  • 7w80 – mARNT + mHIF-2 + drug
    
  • 5nj8 – mARNT 85-345 + AHR + DNA
    
  • 7vni – mARNT 85-345 + DmAHR
    
  • 7v7l, 7v7w – mARNT + mHIF-3
    
  • 5sy5 – mARNT + NPAS1
    
  • 5sy7 – mARNT + NPAS3 + DNA
    
  • 7xhv, 7xi4 – mARNT + NPAS4 + DNA
    
• HIF-2α or endothelial PAS domain-containing protein
  • 1p97 – hHIF-2 C-terminal PAS - NMR
    
  • 5kiz – hHIF-2 PAS-B – NMR
    
  • 3f1n, 3f1o, 3f1p, 3h7w, 3h82, 4ghi, 6d0c – hHIF-2 PAS-B (mutant) + ARNT
    
  • 6czw, 6d09, 6d0b, 6x21, 6x28, 6x2h, 6x37, 6x3d – hHIF-2 PAS-B (mutant) + ARNT + inhibitor
    
  • 2a24 – hHIF-2 PAS-B (mutant) + ARNT C-terminal PAS - NMR
    
  • 6bvb – hHIF-2 + elongin B + elongin C + pVHL
    
  • 6e3s – mHIF-2 (mutant) + ARNT
    
  • 4zph – mHIF-2 + ARNT + proflavin
    
  • 4zqd, 6e3t – mHIF-2 + ARNT + inhibitor
    
  • 6e3u – mHIF-2 (mutant) + ARNT + agonist
    
• HIF-3
  • 4wn5 – hHIF-3 C-terminal PAS-B
    

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Michal Harel, Openfox