Plasminogen activator

spinqualitylabelsall models Human tissue plasminogen activator light chain catalytic domain (sky blue and green), heavy chain catalytic domain fragment (yellow and pink) complex with benzamidine, 1a5h Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2. Tissue PLA (TPA) which is involved in breakdown of blood clots. Urokinase-type PLA see Urokinase. Coagulase/fibrinolysin is a plasminogen activator from Yersinia pestis which possesses coagulase activity is responsible for degradation of plasmid-coded outer membrane proteins. Relevance Treatment with tissue PLA for acute ischemic stroke is beneficial. Structural highlights Interactions between tissue plasminogen activator light chain catalytic domain and heavy chain catalytic domain fragment. Water molecules are shown as red spheres. Benzamidine binding site.

3D structures of plasminogen activator

Urokinase

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Openfox