Plectin

spinqualitylabelsall models Mouse plectin actin-binding domain 1sh6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure . C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin, . N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues 300-1372) and N-terminal arm, which varies among isoforms. For more details see Group:MUZIC:Plectin. Disease Mutations in plectin result in skin fragility and blister formation.

3D structures of plectin

Plectin 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Jae-Geun Song, Michal Harel, Alexander Berchansky