Structural highlights
Function
I4OMT_GLYEC 2-hydroxyisoflavanone 4'-O-methyltransferase involved in the biosynthesis of formononetin. Can use 2,7,4'-trihydroxyisoflavanone, (+)-6a-hydroxymaackiain or medicarpin as substrate, but not daidzein or (-)-6a-hydroxymaackiain.[1] [2]
References
- ↑ Akashi T, Sawada Y, Shimada N, Sakurai N, Aoki T, Ayabe S. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway. Plant Cell Physiol. 2003 Feb;44(2):103-12. PMID:12610212 doi:10.1093/pcp/pcg034
- ↑ Akashi T, VanEtten HD, Sawada Y, Wasmann CC, Uchiyama H, Ayabe S. Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis. Phytochemistry. 2006 Dec;67(23):2525-30. PMID:17067644 doi:10.1016/j.phytochem.2006.09.010
