Structural highlights
9rlb is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.89Å |
| Ligands: | BR, CL, IMD, ISO, MES, MPD |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
FHMAD_MYCTU Catalyzes the coenzyme F420-dependent oxidation of hydroxymycolic acids (H-MAs) to ketomycolic acids (K-MAs), a lipid class making up the mycobacterial pseudo-outer membrane and over one-third of the dry weight of M.tuberculosis (PubMed:24349169). Does not exhibit F420-dependent glucose-6-phosphate dehydrogenase (FGD) activity (PubMed:23110042).[1] [2]
References
- ↑ Bashiri G, Perkowski EF, Turner AP, Feltcher ME, Braunstein M, Baker EN. Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis. PLoS One. 2012;7(10):e45003. PMID:23110042 doi:10.1371/journal.pone.0045003
- ↑ Purwantini E, Mukhopadhyay B. Rv0132c of Mycobacterium tuberculosis encodes a coenzyme F420-dependent hydroxymycolic acid dehydrogenase. PLoS One. 2013 Dec 11;8(12):e81985. PMID:24349169 doi:10.1371/journal.pone.0081985
