13io | pdb_000013io

MCU-EMRE complex with spermine

Structural highlights

13io is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.98Å
Ligands:	CA, CDL, P5S, SPM
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EMRE_HUMAN Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988).^[1] ^[2] ^[3]

References

↑ Sancak Y, Markhard AL, Kitami T, Kovacs-Bogdan E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013, Nov 14. PMID:24231807 doi:https://dx.doi.org/10.1126/science.1242993
↑ Vais H, Mallilankaraman K, Mak DD, Hoff H, Payne R, Tanis JE, Foskett JK. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Rep. 2016 Jan 26;14(3):403-410. doi: 10.1016/j.celrep.2015.12.054. Epub 2016, Jan 7. PMID:26774479 doi:https://dx.doi.org/10.1016/j.celrep.2015.12.054
↑ Tsai MF, Phillips CB, Ranaghan M, Tsai CW, Wu Y, Willliams C, Miller C. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Elife. 2016 Apr 21;5. doi: 10.7554/eLife.15545. PMID:27099988 doi:https://dx.doi.org/10.7554/eLife.15545

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OCA

[1] Sancak Y, Markhard AL, Kitami T, Kovacs-Bogdan E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013, Nov 14. PMID:24231807 doi:https://dx.doi.org/10.1126/science.1242993

[2] Vais H, Mallilankaraman K, Mak DD, Hoff H, Payne R, Tanis JE, Foskett JK. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Rep. 2016 Jan 26;14(3):403-410. doi: 10.1016/j.celrep.2015.12.054. Epub 2016, Jan 7. PMID:26774479 doi:https://dx.doi.org/10.1016/j.celrep.2015.12.054

[3] Tsai MF, Phillips CB, Ranaghan M, Tsai CW, Wu Y, Willliams C, Miller C. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Elife. 2016 Apr 21;5. doi: 10.7554/eLife.15545. PMID:27099988 doi:https://dx.doi.org/10.7554/eLife.15545

[1]

[2]

[3]

13io | pdb_000013io

MCU-EMRE complex with spermine

Structural highlights

Function

References

Contents

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