Structural highlights
Function
CAPSD_HASVA The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the immature VP70 virion.[UniProtKB:Q9IFX1] Self-assembles to form an icosahedral capsid with a T=3 symmetry, about 43 nm in diameter.[UniProtKB:O12792] Forms the spikes at the surface of the virion (PubMed:38416796). Plays a role in the attachment to target host cell (By similarity).[UniProtKB:O12792][1]
References
- ↑ Ghosh A, Delgado-Cunningham K, Lopez T, Green K, Arias CF, DuBois RM. Structure and antigenicity of the divergent human astrovirus VA1 capsid spike. PLoS Pathog. 2024 Feb 28;20(2):e1012028. doi: 10.1371/journal.ppat.1012028. , eCollection 2024 Feb. PMID:38416796 doi:https://dx.doi.org/10.1371/journal.ppat.1012028