Prolyl endopeptidase 3D structures

3D structures of prolyl endopeptidase

Updated on 19-July-2026

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• Prolyl endopeptidase open state
  • 3iun, 3ium, 3iul, 3iuj – ApPEP - Aeromonas punctata
    
  • 3iur – ApPEP + villin headpiece peptide
• Prolyl endopeptidase closed state
  • 3iuq, 3ivm - ApPEP + z-pro-prolinal
    
  • 3muo – ApPEP (mutant) + z-pro-prolinal
    
  • 3mun - ApPEP (mutant)
• Prolyl endopeptidase
  • 9q5g – hPEP 1-727 - human
    
  • 7obm – hPEP 90-727
    
  • 1h2w, 1qfm – pPEP - pig
    
  • 1vz2, 1vz3, 1h2x, 1e5t, 4ax4 – pPEP (mutant)
    
  • 6jci, 6jym – PEP - abalone
    
  • 1yr2 – PEP – Novosphingobium capsulatum
    
  • 6can – PfPEP (mutant) - Pyrococcus furiosus
    
  • 6jym – HdhPEP – Haliotis discus hannai
    
  • 9hji – PEP – Trypanosoma cruzi
    
• Prolyl endopeptidase complex
  • 3ddu, 9q5x, 9q5y, 9q5z, 9q62, 9q64, 9q65, 9q66, 9q6i, 9q8j, 9q6k, 9q6l, 9q6x, 9xyk, 9xyl, 9xzz – hPEP + inhibitor
    
  • 6y0f – hPEP + drug
    
  • 2xdw – pPEP + peptide
    
  • 1uoo, 1uop, 1uoq, 1o6f, 1o6g, 1h2z, 1e8n - pPEP (mutant) + peptide
    
  • 1h2y - pPEP (mutant) + z-pro-prolinal
    
  • 1qfs - pPEP + z-pro-prolinal
    
  • 3eq7, 3eq8, 3eq9 – pPEP + benzyloxy-carbonyl-gly-pro inhibitor
    
  • 1e8m - pPEP + pro-(decarboxy-pro) inhibitor
    
  • 4amy, 4amz, 4an0, 4an1, 4bcb, 4bcc, 4bcd - pPEP + pyrrolidine derivative inhibitor
    
  • 6jci - HdhPEP + pyrrolidine derivative inhibitor
    
  • 2bkl - PEP + z-ala-prolinal – Myxococcus xanthus
    
  • 5t88 - PfPEP + Pro
    
  • 7zb0, 7zb1 – OoPEP (mutant) + DNA – Omphalotus olearius
    
  • 7zaz – OoPEP + prolyl derivative
    
• Neprosine
  • 7zva, 7zvb, 7zvc – NvNEP – Nepenthes ventricosa
    
  • 9qr8 – NvNEP (mutant)
    
  • 7zu8 – NvNEP + crystallophore
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel