Polyl hydroxylase domain 3D structures

Updated on 20-July-2026

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• Prolyl hydroxylase domain-containing protein 1 catalytic domain 181-407
  • 5v1b - hPHD1 + Fe + inhibitor - human
    
• Prolyl hydroxylase domain-containing protein 2 containing Mn catalytic domain 181-426
  • 5l9r - hPHD2 (mutant) + Mn + 2OG
    
  • 3hqr, 5l9b - hPHD2 (mutant) + Mn + HIF 1 α C terminal + 2OG
    
  • 5l9v, 5la9, 5las - hPHD2 (mutant) + Mn + HIF NODD domain + 2OG
    
  • 4bqw, 4bqx, 4bqy - hPHD2 + Mn + quinoline derivative
    
  • 6st3 - hPHD2 + Mn + pyrimidine derivative
    
  • 5a3u, 6qgv, 6st3, 6yvt, 6zbn, 6zbo, 8j1k, 8y0v - hPHD2 + Mn + inhibitor
    
  • 5ox5, 5ox6 - hPHD2 + Mn + drug
    
  • 4uwd, 5lat, 5lb6, 5lbb, 5lbc, 5lbe, 5lbf - hPHD2 (mutant) + Mn + quinoline derivative
    
  • 6yvx, 6yvz - hPHD2 + Mn + peptide
    
  • 6yw3, 7q5v, 7q5x - hPHD2 + Mn + peptide + oxalylglycine
    
  • 6yw1, 6yw2, 6yw4 - hPHD2 (mutant) + Mn + peptide + oxalylglycine
    
• Prolyl hydroxylase domain-containing protein catalytic domain containing other metal ions
  • 2y33 – hPHD2 + Zn + quinoline derivative
    
  • 3ouh, 3oui, 5v18, 6nmq, 6yvw, 6yw0, 8z31, 8z32, 8z33, 8z35 - hPHD2 + Fe + inhibitor
    
  • 4kbz - hPHD2 (mutant) + Fe + inhibitor
    
  • 4jzr - hPHD2 + Ni + inhibitor
    
  • 3ouj - hPHD2 + Fe + 2OG
    
  • 3hqu - hPHD2 + Fe + HIF 1 α C terminal + quinoline derivative
    
  • 2hbt, 2hbu, 2g19, 2g1m, 2y34, 4bqi - hPHD2 + Fe + quinoline derivative
    
  • 5v18 - hPHD2 + Fe + pyridine derivative
    
  • 6nmq - hPHD2 + Fe + inhibitor
    
  • 7ump - hPHD2 + Fe + drug
    
  • 8q6d, 8q6e - hPHD2 + Fe + peptide + oxoglutarate
    
  • 8rut, 8ruv - hPHD2 (mutant) + Fe + peptide + oxoglutarate
    
  • 8q5s - hPHD2 + peptide + acetate
    
  • 8ruz, 8rv1 - hPHD2 (mutant) + peptide + acetate
    
  • 8q64 – hPHD2 + peptide
    
  • 7ujv - hPHD2 + Fe + peptide + oxalylglycine
    

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Michal Harel