Structural highlights
Function
PG070_VACCW May play a role in the biogenesis of the viral factories by recruiting and wrapping DNA replication sites in endoplasmic reticulum derived membranes. Later in infection, phosphorylation by the late viral kinase OPG054/F10L might decrease DNA-binding ability and trigger ER membranes disassembly. Binds DNA in vitro.[1]
References
- ↑ Doglio L, De Marco A, Schleich S, Roos N, Krijnse Locker J. The Vaccinia virus E8R gene product: a viral membrane protein that is made early in infection and packaged into the virions' core. J Virol. 2002 Oct;76(19):9773-86. PMID:12208956 doi:10.1128/jvi.76.19.9773-9786.2002