31hp | pdb_000031hp

Crystal structure of tau tubulin kinase 2 (TTBK2) in complex with compound 62

spinqualitylabelsall models 31hp, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 31hp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: A1J95, EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease TTBK2_HUMAN Spinocerebellar ataxia type 11. The disease is caused by mutations affecting the gene represented in this entry. Function TTBK2_HUMAN Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.

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