9s2f | pdb_00009s2f

Human debranched intron spliceosome (DIS)

spinqualitylabelsall models 9s2f, resolution 3.14Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9s2f is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.14Å Ligands: GTP, IHP, MG, SEP, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DHX35_HUMAN Acts as a co-sensor in RIGI-mediated antiviral innate immunity (PubMed:39037956). Enhances RIGI recognition of viral nucleic acids and interacts with RIGI and MAVS to form a signaling complex which triggers downstream signaling cascades that lead to the induction of type I interferons and pro-inflammatory cytokines during the antiviral innate immune response (PubMed:39037956).

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