| Structural highlights
Function
PADI6_MOUSE Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development (PubMed:16137333, PubMed:17587491, PubMed:18599511, PubMed:27929740, PubMed:37922900). Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins and proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:18599511, PubMed:37922900, PubMed:38453481). In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+) (By similarity).[UniProtKB:Q6TGC4][1] [2] [3] [4] [5] [6]
References
- ↑ Liu M, Oh A, Calarco P, Yamada M, Coonrod SA, Talbot P. Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development. Reprod Biol Endocrinol. 2005 Sep 1;3:42. doi: 10.1186/1477-7827-3-42. PMID:16137333 doi:https://dx.doi.org/10.1186/1477-7827-3-42
- ↑ Esposito G, Vitale AM, Leijten FP, Strik AM, Koonen-Reemst AM, Yurttas P, Robben TJ, Coonrod S, Gossen JA. Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol. 2007 Jul 15;273(1-2):25-31. doi: 10.1016/j.mce.2007.05.005. , Epub 2007 May 17. PMID:17587491 doi:https://dx.doi.org/10.1016/j.mce.2007.05.005
- ↑ Yurttas P, Vitale AM, Fitzhenry RJ, Cohen-Gould L, Wu W, Gossen JA, Coonrod SA. Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo. Development (Cambridge, England). 2008 Aug 1. doi: 10.1242/dev.016329. PMID: 18599511.
- ↑ Liu X, Morency E, Li T, Qin H, Zhang X, Zhang X, Coonrod S. Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices. Cell Cycle. 2017 Feb 16;16(4):360-366. doi: 10.1080/15384101.2016.1261225. Epub , 2016 Dec 8. PMID:27929740 doi:https://dx.doi.org/10.1080/15384101.2016.1261225
- ↑ Jentoft IMA, Bäuerlein FJB, Welp LM, Cooper BH, Petrovic A, So C, Penir SM, Politi AZ, Horokhovskyi Y, Takala I, Eckel H, Moltrecht R, Lénárt P, Cavazza T, Liepe J, Brose N, Urlaub H, Fernández-Busnadiego R, Schuh M. Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices. Cell. 2023 Nov 22;186(24):5308-5327.e25. PMID:37922900 doi:10.1016/j.cell.2023.10.003
- ↑ Giaccari C, Cecere F, Argenziano L, Pagano A, Galvao A, Acampora D, Rossi G, Hay Mele B, Acurzio B, Coonrod S, Cubellis MV, Cerrato F, Andrews S, Cecconi S, Kelsey G, Riccio A. A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos. Genes & development. 2024 Mar 22. doi: 10.1101/gad.351238.123. PMID: 38453481.
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