Structural highlights
Function
WALR_STRPN Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism (By similarity). Binds to the promoter region of the transcription factor fabT gene in the fabTH-acp operon in vitro (PubMed:27610104). Inhibits transcription of fabT, probably acting in an unphosphorylated form, thereby playing a role in the regulation of fatty acid biosynthesis (PubMed:15774879, PubMed:27610104). Essential for normal growth in vitro (By similarity). Required for maintaining normal cellular morphology, acting, at least in part, by regulating peptidoglycan hydrolase pcsB (By similarity). Involved in maintaining expression of WalRK regulon genes in exponentially growing cells (By similarity).[UniProtKB:A0A0H2ZN37][UniProtKB:P37478][UniProtKB:Q8DPL7][1] [2]
References
- ↑ Mohedano ML, Overweg K, de la Fuente A, Reuter M, Altabe S, Mulholland F, de Mendoza D, López P, Wells JM. Evidence that the essential response regulator YycF in Streptococcus pneumoniae modulates expression of fatty acid biosynthesis genes and alters membrane composition. J Bacteriol. 2005 Apr;187(7):2357-67. PMID:15774879 doi:10.1128/JB.187.7.2357-2367.2005
- ↑ Mohedano ML, Amblar M, de la Fuente A, Wells JM, López P. The Response Regulator YycF Inhibits Expression of the Fatty Acid Biosynthesis Repressor FabT in Streptococcus pneumoniae. Front Microbiol. 2016 Aug 25;7:1326. PMID:27610104 doi:10.3389/fmicb.2016.01326