Structural highlights
7e5q is a 2 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.9Å |
| Ligands: | CIT, CL, EDO, GOL, HEM, NA, OXY, PEG |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
EFEB_BACSU Involved in the recovery of exogenous heme iron (By similarity). Extracts iron from heme while preserving the protoporphyrin ring intact (By similarity). Part of the iron transporter system efeUOB/M involved in iron import (PubMed:16672620, PubMed:23764491). Catalyzes the peroxide-mediated oxidation of Fe(2+) into Fe(3+); EfeM binds Fe(3+) and delivers it to the cell membrane permease EfeU (PubMed:23764491).[UniProtKB:P31545][1] [2]
References
- ↑ Ollinger J, Song KB, Antelmann H, Hecker M, Helmann JD. Role of the Fur regulon in iron transport in Bacillus subtilis. J Bacteriol. 2006 May;188(10):3664-73. PMID:16672620 doi:https://dx.doi.org/188/10/3664
- ↑ Miethke M, Monteferrante CG, Marahiel MA, van Dijl JM. The Bacillus subtilis EfeUOB transporter is essential for high-affinity acquisition of ferrous and ferric iron. Biochim Biophys Acta. 2013 Oct;1833(10):2267-78. doi: , 10.1016/j.bbamcr.2013.05.027. Epub 2013 Jun 10. PMID:23764491 doi:https://dx.doi.org/10.1016/j.bbamcr.2013.05.027