Pyridoxine 5'-phosphate oxidase

spinqualitylabelsall models Pyridoxine 5-phosphate oxidase dimer complex with pyridoxine 5-phosphate, 2aq6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pyridoxine 5’-phosphate oxidase or Pyridoxamine 5’-phosphate oxidase (PNPO) catalyzes the oxidation of pyridoxamine-phosphate by molecular oxygen producing pyridoxal 5’-phosphate, ammonia and hydrogen peroxide. Pyridoxal 5’-phosphate (PLP), commonly known as vitamin B6, is a biological essential cofactor. PNPO catalyzes the last step in vitamin B6 metabolism. PNPO uses FMN as cofactor. Disease PNPO mutations are present in epilepsy patients. Structural highlights The active site of PNPO shows the product of PNPO catalysis - PLP - interacting with both subunits of the enzyme. Water molecules are shown as red spheres.

3D structures of pyridoxine 5'-phosphate oxidase

Updated on 20-August-2026

1nrg, 8qyt - hPNPO + PLP – human
8ros - hPNPO + PLP derivative
3hy8 - hPNPO (mutant) + PLP
6h00, 8qyw – hPNPO (mutant) + FMN
2aq6 - MtPNPO + PLP – Mycobacterium tuberculosis
1y30 - MtPNPO + FMN
1xxo - MtPNPO
1dnl, 1g76, 1wv4 – EcPNPO – Escherichia coli
1g76, 1g77, 1g78, 1g79, 1jnw – EcPPO + PLP
6ylz – EcPNPO (mutant) + FMN + Pi
6ymh – EcPNPO (mutant) + FMN + PLP
4hmw – BlPNPO + FMN – Burkholderia lata
4hmx – BlPNPO + FMN + phenazine carboxylic acid
4hms – PfPNPO + FMN – Pseudomonas fluorescense
4hmt, 4hmu, 4hmv – PfPNPO + FMN + phenazine carboxylic acid

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