Proto-oncogene serine/threonine protein kinase 3D structures

Proto-oncogene serine/threonine protein kinase

Updated on 24-August-2026

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• Rac-α hChk (AKT1); domains: pleckstrin homology 1-123;kinase 144-480
  • 1unp, 1unr – Rac-α hChk pleckstrin homology domain <br /
  • 2uzr, 2uzs, 7myx – hRac-α hChk pleckstrin homologydomain (mutant)
    
  • 1h10, 1unq, 2uvm – hRac-α hChk pleckstrin homology domain + inositol tetrakisphosphate
    
  • 3o96, 4ejn, 6hhf, 6hhg, 6hhh, 6hhi, 6hhj, 6s9w, 6s9x - hRac-α hChk + inhibitor
    
  • 5kcv, 7nh4, 7nh5 - hRac-α hChk (mutant) + inhibitor
    
  • 4ekl, 4gv1 - hRac-α hChk kinase domain + inhibitor
    
  • 3qkm, 6ccy - hRac-α hChk kinase domain (mutant) + inhibitor
    
  • 6buu - hRac-α hChk kinase domain + bisubstrate peptide
    
  • 4ekk - hRac-α hChk kinase domain (mutant) + GSK3 peptide + AMPPNP
    
  • 6npz - hRac-α hChk kinase domain + peptide + inhibitor
    
  • 3ow4, 3qkk, 3qkl, 6buu - hRac-α hChk kinase domain (mutant) + peptide + inhibitor
    
  • 7apj - hRac-α hChk + nanobody
    
• Rac-β hChk (AKT2)
  • 1gzk, 1gzn, 1gzo, 1mrv, 1mry – hRac-β hChk kinase domain
    
  • 1p6s - hRac-β hChk pleckstrin homology domain - NMR
    
  • 1o6k - hRac-β hChk kinase domain + GSK3 peptide + AMPPNP
    
  • 2jdo, 2jdr, 2uw9, 2x39, 3cqu, 3cqw - hRac-β hChk kinase domain + GSK3 peptide + inhibitor
    
  • 3e87, 3e88, 3e8d - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
  • 1o6l - hRac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP
    
  • 3d0e, 8q61 - hRac-β hChk kinase domain (mutant) + inhibitor
    
• Rac-γ hChk (ATK3)
  • 2x18 – Rac-γ hChk PH domain
    
• A-Raf
  • 1wxm – hA-Raf RAS-binding domain 19-91 - NMR
    
  • 2mse – hA-Raf RAS-binding domain + APOA-I + K-ras - NMR
    
• B-Raf; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723
  • 8dgs, 8dgt – hB-Raf in Ras/Raf complex – Cryo EM
    
  • 7z37, 7z38, 7zr5 – hB-Raf + Hsp90 + CDC37 + PP5 – Cryo EM
    
  • 1uwh, 3c4c, 6v2u, 6xfp, 6xlo, 8f7o, 8f7p – hB-Raf kinase domain + anticancer drug
    
  • 1uwj, 6p3d – hB-Raf kinase domain (mutant) + anticancer drug
    
  • 2fb8, 3d4q, 3e26, 3ii5, 3ppj, 3ppk, 3prf, 3pri, 3psb, 3psd, 3q4c, 3q96, 3skc, 3tv4, 3tv6, 4dbn, 4e26, 4e4x, 4ehe, 4fc0, 4g9c, 4h58, 4ksp, 4ksq, 4mbj, 4pp7, 6cad, 7shv – hB-Raf kinase domain + pyrazole inhibitor
    
  • 3idp, 4ehg, 4fk3, 4g9r, 4jvg, 4mnf, 4r5y, 4rzv, 4rzw, 4wo5, 4xv1, 4xv2, 4xv3, 4xv9, 4yht, 5c9c, 5hi2, 5ita, 5jrq, 5jsm, 5jt2, 6nsq, 6p7d, 6uuo – hB-Raf kinase domain (mutant) + pyrazole inhibitor
    
  • 5csw, 5csx, 5ct7, 5fd2, 5hid, 5hie, 5val, 5vam, 6b8u, 6n0p, 6n0q, 7k0v, 7p3b, 7p3v, 8c7x, 8c7y - hB-Raf kinaseqdomain + inhibitor
    
  • 6v34 – hB-Raf kinase domain (mutant) + inhibitor
    
  • 4mne – hB-Raf kinase domain + MAPKK1
    
  • 8f7o – hB-Raf kinase domain + drug
    
  • 7m0u – hB-Raf kinase domain + AMPPNP + drug
    
  • 6u2h – hB-Raf kinase domain + 14-3-3 ζ/δ
    
  • 7mfe – hB-Raf + 14-3-3 ζ/δ – Cryo EM
    
  • 7mff – hB-Raf + 14-3-3 ζ/δ + inhibitor – Cryo EM
    
  • 7mfd – hB-Raf + 14-3-3 ζ/δ + MEK + inhibitor – Cryo EM
    
  • 6pp9 – hB-Raf kinase domain + MEK1 + ANP
    
  • 7m0x, 7m0z – hB-Raf kinase domain + MEK1 + ANP + inhibitor
    
  • 7m0t, 7m0u, 7m0v, 7m0w, 7m0y – hB-Raf kinase domain + MEK1 + ANP + drug
    
  • 6u2g – hB-Raf kinase domain + MEK1 + AMPPCP
    
  • 5vr3 – hB-Raf BRS domain
    
  • 7jhp – hB-Raf BRS domain + Hras
    
  • 6ntc, 6ntd – hB-Raf BRS domain (mutant) + Hras
    
  • 6xi7 – hB-Raf 52-188 + Kras
    
  • 2l05, 5j17, 5j2r – hB-Raf RAS-binding domain - NMR
    
  • 3ny5 – hB-Raf RAS-binding domain
    
  • 5j18 – hB-Raf RAS-binding domain + inhibitor - NMR
    
  • 6pts, 6ptw – hB-Raf 56-187 + Kras + apolipoprotein + GMPPNP - NMR
    
  • 6q0k, 6uan – hB-Raf + 14-3-3 ζ – Cryo EM
    
  • 6nyb – hB-Raf + 14-3-3 ζ + MEK1 – Cryo EM
    
  • 6q0j, 6q0t – hB-Raf (mutant) + 14-3-3 ζ + MEK1 – Cryo EM
    
• c-Raf; Domains – RAS-binding (RBD) 55-132; Cys-rich 136-187 (CBD); kinase 323-618
  • 1rfa, 8jna, 8jof, 8jog – hc-Raf RBD - NMR
    
  • 1faq, 1far – hc-Raf cysteine-rich domain - NMR
    
  • 3omv – hc-Raf kinase domain
    
  • 1rrb – c-Raf RBD – NMR - rat
    
• c-Raf complex with protein
  • 8cpd – hc-Raf + 14-3-3 protein zeta – Cryo EM
    
  • 9mmp – hc-Raf + MEK1 + 14-3-3 protein zeta – Cryo EM
    
  • 9mmr – hc-Raf (mutant) + MEK1 + 14-3-3 protein zeta – Cryo EM
    
  • 1c1y – hc-Raf RBD + RAP1A
    
  • 3kuc – hc-Raf RBD (mutant) + RAP1A
    
  • 1gua – hc-Raf RBD + RAP1A + GPPNHP
    
  • 8jnb – hc-Raf RBD + ligand
    
  • 4g0n, 4g3x – hc-Raf RBD + GTPase Hras
    
  • 3kud – hc-Raf RBD (mutant) + GTPase Hras
    
  • 8epw, 8t74 – hc-Raf RBD + GTPase K-ras
    
  • 8t75, 9ygs – hc-Raf RBD-CRD + GTPase K-ras + GMPPNP
    
  • 9ay7, 9aya – hc-Raf + MEK1
    
  • 9mmq – hc-Raf + MEK1 – Cryo EM
    
  • 9mms – hc-Raf (mutant) + MEK1 – Cryo EM
    
  • 9o0u, 9o0v – hc-Raf (mutant) + MEK1 + ANP + inhibitor– Cryo EM
    
  • 8u1l – hc-Raf + Hsp90 + CDC37 – Cryo EM
    
  • 8gae, 8gft – hc-Raf + Hsp90 + CDC37 + PP5 – Cryo EM
    
• Pim1 catalytic domain residues 14-313
  • 1xqz, 1ywv, 4jx3 – hPim1 catalytic domain
    
  • 1yxs – hPim1 catalytic domain (mutant)
    
  • 1xr1, 1yxt – hPim1 catalytic domain + AMPPNP
    
  • 1yxu – hPim1 catalytic domain + AMP
    
  • 1yxv, 5ipj – hPim1 catalytic domain + quinoline derivative
    
  • 1yxx – hPim1 catalytic domain + indole derivative
    
  • 2bzh, 2bzi, 2bzj – hPim1 catalytic domain (mutant) + organometallic ligand
    
  • 2o3p, 2o63, 2o64, 2o65, 3c4e, 3jxw, 3jy0, 3jya, 3r00, 3r01, 3r02, 3r04, 3vbq, 3vbt, 3vbv, 3vbw, 3vbx, 3vby, 3vc4, 3umw, 3umx, 4enx, 4eny, 4k0y, 4k18, 4k1b, 4i41, 4iaa, 4ll5, 4lm5, 4lmu, 4mbi, 4mbl, 4med, 4mta, 4n6y, 4n6z, 4n70, 4xh6, 5iis, 5kgd, 5kge, 5kgg, 5kgi, 5kgk, 5kzi, 5vua, 5vub, 5vuc, 6mt0, 6vrv, 7oov, 7oow, 7oox, 7xsv – hPim1 catalytic domain + inhibitor
    
  • 2j2i, 3we8 – hPim1 catalytic domain (mutant)+ inhibitor
    
• Pim1 kinase domain residues 92-404
  • 4jx3 – hPim1 kinase domain
    
  • 3uix, 5c1q – hPim1 kinase domain residues 120-404 + quinoline derivative
    
  • 3a99 – hPim1 kinase domain + phosphoaminophosphonic acid adenylate
    
  • 2oi4, 3bwf – hPim1 kinase domain (mutant) + organometallic ligand
    
  • 1xws, 4alu, 4alv, 4alw, 4as0, 4bzn, 4bzo, 4dtk, 4jx7, 4rbl, 4rc2, 4rc3, 4rc4, 4ty1, 4wrs, 4wsy, 4wt6, 4xhk, 5dgz, 5dhj, 5dia, 5dwr, 5eol, 5kcx, 5o11, 5o12, 5o13, 5tel, 5tex, 5toe, 5v80, 5v82. 6bsk, 6kzi, 6l11, 6l12, 6l13, 6l14, 6l15, 6l16, 6l17, 6no8, 6no9, 6vru, 6ykd, 7zun – hPim1 kinase domain + inhibitor
    
  • 6ayd – hPim1 kinase domain (mutant)+ inhibitor
    
• Pim1 full length
  • 4rpv, 5tur - hPim1 + inhibitor
    
• Pim1 complex with consensus peptide (pimtide)
  • 2bil, 3cxw, 3cy2, 3cy3, 6pcw, 6pdi, 6pdn, 6pdo, 6pdp, 6qxk – hPim1 kinase domain + inhibitor + consensus peptide
    
  • 3jpv, 3qf9 - hPim1 catalytic domain + inhibitor + consensus peptide
    
  • 2c3i, 5mzl, 5n4n, 5n4o, 5n4r, 5n4u, 5n4v, 5n4x, 5n4y, 5n4z, 5n50, 5n51, 5n52, 5n5l, 5n5m, 5ndt – hPim1 kinase domain (mutant) + inhibitor + consensus peptide
    
  • 4gw8, 7qb2, 7qfm, 7z6u, 8afr – hPim1 catalytic domain (mutant) + inhibitor + pimtide
    
  • 2bzk – hPim1 kinase domain (mutant)+ AMPPNP + consensus peptide
    
  • 3ma3 – hPim1 catalytic domain + inhibitor + PSer + consensus peptide
    
• Pim1 containing phosphorylated Ser 261
  • 1yhs – hPim1 kinase domain + PSer + staurosporine
    
  • 1yi3, 2bik, 2xix, 2xiy, 2xiz, 2xj0, 2xj1, 2xj2, 4a7c – hPim1 kinase domain + PSer + inhibitor
    
  • 2obj, 3bgp, 3bgq, 3bgz, 3dcv, 3f2a, 3t9i - hPim1 catalytic domain + PSer + inhibitor
    
  • 1yi4 – hPim1 kinase domain + PSer + adenosine
    
• Pim2
  • 4x7q – hPim2 catalytic domain + inhibitor
    
  • 2iwi – hPim2 catalytic domain + Ru ligand
    

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Michal Harel