38go | pdb_000038go
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Revision as of 16:46, 8 September 2026 by OCA (talk | contribs) (Created page with " ==Crystal structure of MALT1 in complex with safimaltib== <StructureSection load='38go' size='340' side='right'caption='38go, resolution 2.07Å' scene=''> == Structural highlights == <table><tr><td colspan='2'>38go is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=38GO OCA]. For a <b>guided...")
Crystal structure of MALT1 in complex with safimaltib
Structural highlights
DiseaseMALT1_HUMAN Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. FunctionMALT1_HUMAN Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.[1] [2] [3] References
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