Structural highlights
Function
PBN1_YEAST Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Aids the autocatalytic processing of PRB1. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.[1] [2] [3]
References
- ↑ Ashida H, Hong Y, Murakami Y, Shishioh N, Sugimoto N, Kim YU, Maeda Y, Kinoshita T. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Mol Biol Cell. 2005 Mar;16(3):1439-48. doi: 10.1091/mbc.e04-09-0802. Epub 2005 , Jan 5. PMID:15635094 doi:https://dx.doi.org/10.1091/mbc.e04-09-0802
- ↑ Subramanian S, Woolford CA, Drill E, Lu M, Jones EW. Pbn1p: an essential endoplasmic reticulum membrane protein required for protein processing in the endoplasmic reticulum of budding yeast. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):939-44. doi: , 10.1073/pnas.0505570103. Epub 2006 Jan 17. PMID:16418276 doi:https://dx.doi.org/10.1073/pnas.0505570103
- ↑ Naik RR, Jones EW. The PBN1 gene of Saccharomyces cerevisiae: an essential gene that is required for the post-translational processing of the protease B precursor. Genetics. 1998 Jul;149(3):1277-92. doi: 10.1093/genetics/149.3.1277. PMID:9649520 doi:https://dx.doi.org/10.1093/genetics/149.3.1277
