Structural highlights
Function
DEPOL_BPKN1 Functions as a receptor binding protein (RBP) and probably mediates the attachment to the host capsular exopolysaccharides (Probable). Displays a depolymerase activity that specifically degrades the KN1-type polysaccharides of Klebsiella pneumoniae capsule, which allows the phage to reach the host cell membrane and bind the entry receptor (PubMed:30706654).[1] [2]
References
- ↑ Pan YJ, Lin TL, Chen YY, Lai PH, Tsai YT, Hsu CR, Hsieh PF, Lin YT, Wang JT. Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types. Microb Biotechnol. 2019 May;12(3):472-486. doi: 10.1111/1751-7915.13370. Epub , 2019 Jan 31. PMID:30706654 doi:https://dx.doi.org/10.1111/1751-7915.13370
- ↑ Pan YJ, Lin TL, Chen YY, Lai PH, Tsai YT, Hsu CR, Hsieh PF, Lin YT, Wang JT. Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types. Microb Biotechnol. 2019 May;12(3):472-486. doi: 10.1111/1751-7915.13370. Epub , 2019 Jan 31. PMID:30706654 doi:https://dx.doi.org/10.1111/1751-7915.13370