Structural highlights
9zb2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.01Å |
| Ligands: | A1C1W, EDO, GOL, MN, UDP |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
MGAT1_HUMAN Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.[1] [2]
References
- ↑ Kumar R, Yang J, Larsen RD, Stanley P. Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9948-52. doi: 10.1073/pnas.87.24.9948. PMID:1702225 doi:https://dx.doi.org/10.1073/pnas.87.24.9948
- ↑ Jaroentomeechai T, Kwon YH, Liu Y, Young O, Bhawal R, Wilson JD, Li M, Chapla DG, Moremen KW, Jewett MC, Mizrachi D, DeLisa MP. A universal glycoenzyme biosynthesis pipeline that enables efficient cell-free remodeling of glycans. Nat Commun. 2022 Oct 24;13(1):6325. doi: 10.1038/s41467-022-34029-7. PMID:36280670 doi:https://dx.doi.org/10.1038/s41467-022-34029-7
