9zo8 | pdb_00009zo8

Structure of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)

spinqualitylabelsall models 9zo8, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9zo8 is a 8 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.7Å Ligands: ATP, CA, CFF, PCW, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function FKB1A_RABIT Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

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