Structural highlights
Function
TX11A_TETBN Neurotoxin that causes irreversible rapid flaccid paralysis in blowflies and honeybees upon intrathoracic injection (PubMed:37888631). Causes a quick and irreversible cytolytic effect (at 10 uM) indicating it possibly acts as a pore-forming peptide (PubMed:38786948). Shows only weak effect on aphids (A.pisum) at high doses 24 hours post intrathoracic injection (PubMed:37888631). In vitro, is not cytotoxic on the dipteran S2 Drosophila embryonic cell line (PubMed:37888631).[1] [2]
References
- ↑ Barassé V, Jouvensal L, Boy G, Billet A, Ascoët S, Lefranc B, Leprince J, Dejean A, Lacotte V, Rahioui I, Sivignon C, Gaget K, Ribeiro Lopes M, Calevro F, Da Silva P, Loth K, Paquet F, Treilhou M, Bonnafé E, Touchard A. Discovery of an Insect Neuroactive Helix Ring Peptide from Ant Venom. Toxins (Basel). 2023 Oct 5;15(10):600. PMID:37888631 doi:10.3390/toxins15100600
- ↑ Peigneur S, Tibery D, Tytgat J. The Helix Ring Peptide U(11) from the Venom of the Ant, Tetramorium bicarinatum, Acts as a Putative Pore-Forming Toxin. Membranes (Basel). 2024 May 14;14(5):114. doi: 10.3390/membranes14050114. PMID:38786948 doi:https://dx.doi.org/10.3390/membranes14050114
