2hde | pdb_00002hde
Solution Structure of Human SAP18
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Overview
Signal transduction pathways are frequently found to repress transcription, of target genes in the absence of stimulation and, conversely, to, upregulate transcription in the presence of a signal. Transcription, factors are central in this dual regulatory mechanism and widely use a, generalized mechanism to repress transcription through recruitment of a, Sin3-histone deacetylase (HDAC) complex to their binding sites on DNA. The, protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to, play a key role in gene-specific recruitment of the HDAC complex by a, number of transcription factors including Gli, GAGA, and Bicoid. The, solution structure of SAP18 reveals a ubiquitin-like fold with several, large loop insertions relative to other family members. This fold supports, the functional role of SAP18 as a protein-protein adapter module and, provides insight for how SAP18 may bridge the Sin3-HDAC complex to, transcription factors.
About this Structure
2HDE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly., McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ, Biochemistry. 2006 Oct 3;45(39):11974-82. PMID:17002296
Page seeded by OCA on Mon Nov 12 22:30:42 2007
