2jj2 | pdb_00002jj2

File:2jj2.gif

spinqualitylabelsall models 2jj2, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

THE STRUCTURE OF F1-ATPASE INHIBITED BY QUERCETIN.

Overview

The structures of F(1)-ATPase from bovine heart mitochondria inhibited, with the dietary phytopolyphenol, resveratrol, and with the related, polyphenols quercetin and piceatannol have been determined at 2.3-, 2.4-, and 2.7-A resolution, respectively. The inhibitors bind to a common site, in the inside surface of an annulus made from loops in the three alpha-, and three beta-subunits beneath the "crown" of beta-strands in their, N-terminal domains. This region of F(1)-ATPase forms a bearing to allow, the rotation of the tip of the gamma-subunit inside the annulus during, catalysis. The binding site is a hydrophobic pocket between the C-terminal, tip of the gamma-subunit and the beta(TP) subunit, and the inhibitors are, bound via H-bonds mostly to their hydroxyl moieties mediated by bound, ... [(full description)]

About this Structure

2JJ2 is a [Protein complex] structure of sequences from [Bos taurus] with MG, AZI, PO4, ANP, ADP, QUE and GOL as [ligands]. Active as [[1]], with EC number [3.6.1.34]. Full crystallographic information is available from [OCA].

Reference

Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols., Gledhill JR, Montgomery MG, Leslie AG, Walker JE, Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13632-7. Epub 2007 Aug 13. PMID:17698806

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