2q2z | pdb_00002q2z
Crystal Structure of KSP in Complex with Inhibitor 22
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Overview
Inspired by previous efforts in the pyrazolobenzoxazine class of KSP, inhibitors, the design and synthesis of 1,4-diaryl-4,5-dihydropyrazole, inhibitors of KSP are described. Crystallographic evidence of binding mode, and in vivo potency data is also highlighted.
About this Structure
2Q2Z is a Single protein structure of sequence from Homo sapiens with MG, ADP and MKK as ligands. Full crystallographic information is available from OCA.
Reference
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP., Roecker AJ, Coleman PJ, Mercer SP, Schreier JD, Buser CA, Walsh ES, Hamilton K, Lobell RB, Tao W, Diehl RE, South VJ, Davide JP, Kohl NE, Yan Y, Kuo LC, Li C, Fernandez-Metzler C, Mahan EA, Prueksaritanont T, Hartman GD, Bioorg Med Chem Lett. 2007 Oct 15;17(20):5677-82. Epub 2007 Aug 21. PMID:17766111
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