2icw | pdb_00002icw
Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
Overview
'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
About this Structure
2ICW is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Mycoplasma arthritidis. Full crystallographic information is available from OCA.
Reference
Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC., Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H, Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14. PMID:17220897 Page seeded by OCA on Sun May 4 07:20:38 2008
