2v5z | pdb_00002v5z
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STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR SAFINAMIDE
Overview
Structures of human monoamine oxidase B (MAO B) in complex with safinamide, and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively, inhibit MAO B with Ki values in the 0.1-0.5 muM range that are 30-700-fold, lower than those observed with MAO A. The inhibitors bind noncovalently to, MAO B, occupying both the entrance and the substrate cavities and showing, a similarly oriented benzyloxy substituent.
About this Structure
2V5Z is a Single protein structure of sequence from Homo sapiens with FAD and SAG as ligands. Active as Amine oxidase (flavin-containing), with EC number 1.4.3.4 Structure known Active Sites: AC1, AC2, AC3 and AC4. Full crystallographic information is available from OCA.
Reference
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Oct 4;. PMID:17915852
Page seeded by OCA on Mon Nov 12 23:42:02 2007
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Amine oxidase (flavin-containing)
- Homo sapiens
- Single protein
- Binda, C.
- Caccia, C.
- Carotti, A.
- Edmondson, D.E.
- Mattevi, A.
- Pisani, L.
- Salvati, P.
- Wang, J.
- FAD
- SAG
- Fad
- Flavoprotein
- Human mao b structure
- Membrane
- Mitochondrion
- Neuroprotection
- Oxidoreductase
- Parkinson's disease
- Reversible inhibitor binding
- Safinamide
- Transmembrane
