1bbd | pdb_00001bbd
THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2
|
Overview
The crystal structure of the antigen-binding fragment of a monoclonal, antibody (8F5) that neutralizes human rhinovirus serotype 2 has been, determined by X-ray diffraction studies. Antibody 8F5, obtained by, immunization with native HRV2 virions, cross-reacts with peptides of the, viral capsid protein VP2, which contribute to the neutralizing immunogenic, site B in this serotype. The structure was solved by the molecular, replacement method and has been refined to an R-factor of 18.9% at 2.8 A, resolution. The elbow angle, relating the variable and constant modules of, the molecule is 127 degrees, representing the smallest elbow angle, observed so far in an Fab fragment. Furthermore, the charged residues of, the epitope can be well accommodated in the antigen-binding site. This is, the first crystal structure reported for an antibody directed against an, icosahedral virus.
About this Structure
1BBD is a Protein complex structure of sequences from [1] with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2., Tormo J, Stadler E, Skern T, Auer H, Kanzler O, Betzel C, Blaas D, Fita I, Protein Sci. 1992 Sep;1(9):1154-61. PMID:1338980
Page seeded by OCA on Sun Nov 18 09:26:24 2007
